Universe Clear Particle Preparation Process, Quality Standards Of Paeoniflorin Stability

Migrine, which always brings people sufferings, is a sort of common vascular headache, which occurs from time to time with headaches in one side or both sides of the head, and is often accompanied with nausea and vomiting when it comes. At present, since the incidence of migrine is growing, so far there are few modern medications which are effective and with little side-effects are developed and applied in clinic in treating migrine yet, Chinese Medicine accordingly is drawing much attention with its own advantages.From the theory of Chinese Medicine, the supposed causes for the headache of migrine are the obstructed blood in meridians, which might be caused by the disharmony of mood, the stagnation of liver qi,qi and blood deficiency or the six exogenous pathogenic factors. Accordingly the principles should be calming the liver and suppressing wind, promoting blood circulation to reduce the stasis of blood, strengthening the spleen and resolving phlegm, and strengthening yang to evaporate dampness. In this study, a Chinese herbal preparation which is researched pharmaceutically, is an effective prescription in clinical practice, consists of 10 herbs as Radix Paeoniae Alba (Bai Shao),Rhizoma Gastrodiae (Tian Ma),Rhizoma Chuanxiong (Chuan Xiong), Rhizoma Cyperi(prepared Xiang Fu), Radix Bupleuri(Chai Hu), Radix Scutellariae (Huang Qin), Radix Angelicae Dahuricae (Bai Zhi), Rhizoma Pinelliae (Ban Xia), Rhizoma Corydalis yanhusuo (Yan Hu Suo), Rhizoma Corydalis decumbens (Xia Tian Wu).According to the theory of Chinese Medicine, My research has been going on to the requires of "New TCM Medicine Guide", Experiments in process technology, quality standard and stability of "Qiankunqing granule" was tested. And stability of Paeoniaine affected by temperature, humidity and light were deeply studied. Through the study of the preparation process, we selected the preparation process according to the lipophilic parts and hydrophilic parts with the method of orthogonal to certify the extraction process, and studied the shape process to certify the preparation process.By the study of the quality standard, we certified the method of TCM for Rhizpma Chuanxoing, Rhizoma Corydalis, Rhizoma Corydalis Decumbentis, Radix Bupleuri, Rhizoma Gas trodiae and Radix Scutllariae, certified the method of HPLC for paeoniflorin, and determined the limitation of the paeoniflorin in the preparation and the crude drug.According to the results of the stability experiment of the Qiankunqing granule, each determination complied with the requirements. It indicated that the Qiankunqing granule is generally stable.By the stability experiment of paeoniflorin, we determined the term of validity of thepaeonia albiflora, the extractor of it and the Qianqingkun granule, concluded that the temperature has different effect on the stability of paeoniflorin in different states. The results indicated that the paeoniflorin is unstable in solution and the illumination has no effect on the stability of paeoniflorin.