Inclusion Compounds Of Aromatic Carboxylic Acids Drugs With β-cyclodextrin Derivatives

By the phase solubility method,the thermodynamic parameters in the inclusion reaction of the β-cyclodextrin derivatives with Pranprofen,Carprofen and Ketoprofen are determined.The main contents are as follows:1With the help of UV,HPLC and FD,the solubility of Pranprofen in aqueous solutions of different concentrations of β-cyclodextrin derivatives were measured at different temperatures.The inclusion constants at different temperatures were determined,from which series of thermodynamic parameters were derived. The type of β-cyclodextrin derivatives,concentration, ethanol content,Na2SO4concentration and the pH were investigated.Furthermore, the inclusion complex were characterized by DTA,FT-IR,FD and NMR.The experi-mental results show that:the molar ratio of the inclusion complex of β-cyclodextrin derivatives and Pranprofen is1:1;the solubility of Pranprofen increase with the concentration of β-cyclodextrin derivatives;along with the increase of pH and the temperature, the inclusion constant decreases.2By HPLC and phase solubility method,the differences of inclusion interaction of the β-cyclodextrin derivatives with the racemate of ketoprofen and ketoprofen dextral body were studied.The impacts of factors such as the type of the β-cyclodextrin derivatives and its concentration were investigated,the solubility increases with the increase of cyclodextrin derivatives, the effect of ME-β-CD is obvious.3By the phase solubility method and UV,the factors of the types and the concentration of the β-cyclodextrin derivatives(HP-β-CD,HE-β-CD and ME-β-CD),the temperature on the Carprofen inclusion reaction were investigated. The inclusion complex were characterized by DTA, FTIR,FD and NMR.the molar ratio of the inclusion complex of β-cyclodextrin derivatives and Carprofen is1:1,the order of the effects of the three β-cyclodextrin derivatives were HE-β-CD>HP-β-CD>ME-β-CD.