Study On Slow-release Effect Of Amoxicillin/Mcm-41Loading Drug Systems

The MCM-41molecular sieve was synthesized by a hydrothermal method in the alkaline conditions, and was added methyl and aminopropyl using chlorotrimethylsilane and (3-aminopropyl)trie-thoxysilane as the modifier respectively. The drug of amoxicillin was doped inside the MCM-41molecular sieve and the modified MCM-41molecular sieves via liquid-phase grafting method. The drug release activities of assembled systems were evaluated in simulated body fluid solution. All of the prepared materials were characterized by powder X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), low temperaturee nitrogen adsorption-desorption technique, scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The drug concentration of the amoxicillin in simulated body fluid solution was detected by spectrophotometry.In conclusion, the MCM-41molecular sieves were nanoparticles, and modified by methyl and aminopropyl successfully, the drug release evaluation results show that the last release ratio of MCM-41molecular sieve, methyl MCM-41molecular sieve and ammonopropyl MCM-41molecular sieve were99.58%.92.20%and90.72%after36hours respectively. By contrast, modified MCM-41molecular sieves slow slower release speed than unmodified MCM-41molecular sieve, and ammonopropyl MCM-41molecular sieve is superior to methyl MCM-41molecular sieve.