The Study Of The Synthesis Of Diethyl Malonate By Catalized Carbonylation Method

Diethyl malonate can be used in alkylation, amine alkylation and other substitutionreactions, because of its active methyl group, which is can be easily replaced by othergroups. So it is an important organic chemical intermediates. The widely used method ofSynthesis of Diethyl malonate is sodium cyanide method, But this traditional method(NaCN route) should be improved for its plurality of steps, low yield and environmentpollution problems. So the research of environment-friendly green synthetic process isurgent. But now, researchers are paying more attention to the catalyzed carbonylationmethod, due to its less reactive steps，higher yield, but less environment pollutionproblems.We studied the green synthesizing technology of Diethylmalonic by catalyticcarbonylation, and investigated the effects of the temperature, pressure, feed means andthe types of bases on the carbonylation reaction. The process of synthestic DEM fromethanol and Ethyl chloroacetate (ECA) is studied as follows:Firstly, the free energy change of the reaction△_r G_m~θ, equilibrium constant K~θ wereevaluated according to the chemical thermodynamics principle. The results show that it isuseful for generating DEM, when temperature is not too high.Secondly, we studied the catalytic properties of many catalysts to find out the rightcatalyst, which has high catalytic properties but do no harm to our environment. So that itcan be used in our industrial producting.Thirdly, examined the influence of a variety of reaction conditions on catalytic activityand simplified experimental procedures.Finaly, researched the product analysis in the process of the establishment bychromatographic analysis method.