The Treatment Of Fosfomycin Sodium Wastewater By Hydrolysis Acidification-Biological Contact Oxidation And The Research Of Its Process And Mechanism

In recent years,The appeared of antibiotics in enviorenment has received more andmore attention.This kind of pollutants have high biological activity, high structurestability and strong lipophilicity,so the water ecological environment, water and humanhealth caused serious threat,And these pollutants can also induce and spread of antibioticresistant bacteria and resistant gene.Therefore, the research on the environment ofpollutants antibiotic is especially pressing.Fosfomycin Sodium is a broad spectrum of antibiotics, Because it can restrain thesynthesis of bacterial cell walls, so it can inhibit not only gram-positive bacteria btu alsogram-negative bacteria.The characteristics of fosfomycin sodium wastewater is highCOD value and high concentration of organic phosphorus,So it is a kind of difficultdegradable and has strong biological toxicity of high concentration organic wastewater,At present, the treatment methods are mainly physical and chemical treatment, biologicaltreatment and combined treatment. This paper uses the hydrolytic acidification andcontact oxidation combined process in fosfomycin sodium wastewater treatment.In this experiment, because of fosfomycin sodium pHarmaceutical wastewater withhigh COD of2.0×105mg/L, the total phosphorus concentration is2.5×104mg/Lmg/L,The fosfomycin sodium wastewater was dilutioned. by regulating the differenthydraulic retention time to determination of organic phosphorus removal rate,then studyon the best stage and the last by use the DGGE technical means based on PCR.In the composite process，the volume of the reactor of hydrolysis acidification is20L,filled with elastic filler,and equipped with a heat preservation device to make thereactor in a state of constant temperature of35℃。the volume of the reactor of Contactoxidation is10L,filled with active and suspension property fillers,without heatpreservation device,the Aeration quantity is a fixed value:200L/h. the pH of water inlet isStability in7.5~8,no matter of the concentration of organic phosphorus,and drop to5~6after the hydrolysis acidification process.In this experiment,in order to ensure the waterinlet is continuous,the HRT of hydrolysis acidification reactor was set to two times of the HRT seted for contact oxidation reactorThe impact factor or this research are HRT and the concentration of organicphosphorus,the HRT was set in6h、12h、24h、48h， and the concentration of organicphosphorus were set in5mg/L、10mg/L and20mg/L respectively.Inspected the removalrate of COD and the concentration of organic phosphorus,the result shows:the HRT ofhydrolysis acidification reactor was12h,the COD of water inlet was2000mg/L,theconcentration of organic phosphorus of water inlet was5~10mg/L,the combined processcan reached a quite good treatment effect,not only the COD but also the concentration oforganic phosphorus were removed more than80%.After the test,I tested the selected activated sludge with a technical means namedDGGE,try to analysis the change of microbial community and species in the activatedsludge,the result shows:there is huge difference between the microbial in hydrolysisacidification reactor and in contact oxidation reactor;when the concentration of theinfluent changed,the microbial community makes a corresponding change;the removalof the drug resistance of the pharmaceutical wastewater mainly in the hydrolysisacidification reactor,but the removal of organic phosphorus was happened in the wholereactor.