Umber Aspergillus Fermentation Catalytic Steroid11α-Hydroxyl Chemical Reaction

Steroid hormone drug is the second medicine whose production is just inferior to antibiotic.In the production of steroid hormone drug,some groups of steroid need modifying,11α-hydroxylation is One of the most important ones.Using microbiology enzymatic(P450oxidase)reaction to translate18-methylestr-4-ene-3,17-dione into11-Hydroxy-18-methylestr-4-ene-3,17-dione,there is little report for using the strain Aspergillus Ochraceus tomake this transform.In this papper,the research contect survey and evaluate growth curvature,the reaction for difference sustrate consistency and difference growth cycle,monitor the change of interralated matter in hydroxyl progress,and try to control the pigment generate.