Application Research Of The Computational Fluid Dynamics Simulation Technology In The Bio-reactor

Computational fluid dynamics (CFD) simulation technology has been widely used in reactor design and process optimization. The reactor plays an important role in the bio-oxidation process and the tissue engineering research. Their complex structural features and characteristics of flow field have obvious impact on the growth and metabolism of cells, and then affecting the reactor efficiency. In order to understand the reactor characteristics and optimize the design of the bio-chemical reactor and its process, the inner flow field characteristics of the bio-bleaching reactor and the tissue engineering reactor were investigated by computational fluid dynamics technology (CFD).Firstly, the distribution of the system fluid velocity and shear force field in the bio-bleaching reactor was simulated by the mixture model and the population balance model with the sliding mesh method. The simulation of the velocity field and the shear stress force field distribution in the bioleaching reactor were studied under the condition of the existing and non-existing of the ore particles in the reactor system, through which the effect of the microscopic flow field on the bioleaching experimental results were also analyzed. Simulation results showed that the average shear force in the entire system would increase with the stirring speed under the condition of the existing of the ore particles. However, the process of biological oxidation would be inhibited by the stirring speed of the bioreactor to a certain degree.Secondly, another simulation research of the internal flow field distribution characteristics of the tissue engineering reactor were carried out by the porous model and the volume of fluid (VOF) model.The aim of this study were to predict the relationship between the flow resistance of the reactor scaffold material and the medium diffusion velocity inside. The result showed that the medium movement from inlet to inner area rendering the gradient downward trend. When the perfusion rate was improved, it can effectively increase the reactor internal average flow velocity in the tissue material, however, the fluid shear stress also increased significantly, simultaneously.These study results could provide the important technical support for the optimization of the bio-reactors and their processes.