Study Of Carbonylation By Triphosgene

Triphosgene as a low toxic, stable and eco-friendly chemical product, has a wide range of application in chemical industry and organic synthesis. Using of triphosgene instead of highly toxic phosgene as carbon source for carbonylation can reduce the environmental pollution and enhance the safety of the process with atomic economic reaction efficiency. The introduction of triphosgene into alcohol, amine compounds carbonylation reaction can be used to synthesize chloro formate and N-arylation of phenylurea, developing a highly efficient green synthetic methods.Traditionally, the synthesis of methyl choroformate was prepared by phosgene and methanol as raw material. Considering the toxicity and experimental safety of phosgene, development of low toxic, safe precursors in place of phosgene can meet the require of green chemistry. In the paper, the synthesis of methyl choroformate could be realized by the carbonylation reaction with triphosgene and methanol. The effects of solvents, temperature, time, catalysts on the reaction were screened to optimize the reaction conditions.In addition, N’N-diphenyl urea and its derivatives could be synthesized by the carbonylation with triphosgene and amines. The effects of solvents, temperature, time, catalysts on the reactions to optimize the reaction conditions. A series of its derivatives were also prepared with high yields. Further efforts were also made to explore the one-pot synthesis of N’N-diphenyl urea method. N’N-diphenyl urea could be synthesized directly via a one-pot process using iron or zinc powder as the catalysts, and three other substrates could also provide the desired products under the identical conditions with satisfactory yields and purity.