Water Insoluble Drug For Physical Chemistry Of Solid Dispersions Of Qualitative Research

The aim of this paper are improve the dissolution rate and bioavailabilityof the poorly water soluble drug. So used solid dispersions（SDs）technologyto investigate the effect of the dissolution rate and physicochemicalcharacterization of the SDs prepare with various hydrophilic carry anddifferent preparation method. This research choose the cilostazol as themodel drug, The solubility of pure cilostazol in water was about6.8μg/ml, andthe dissolution rate was less than8%during the2hours. So, used the sodiumlauryl sulfate(SLS), poloxmaer188, Tween80as the surfactant to do thesolubility test. Based on solubility test, SLS was chosen as a optimalsurfactant, which increased solubility about200-fold compared with drugalone. The hydrophilic polymers including poloxamer407, hydroxypropylmethylcellulose(HPMC), polyvinylpyrrolidone(PVP) and polyethyleneglycol6000(PEG6000),were selected as SD carriers. The SDs of the cilostazol wereprepared by the melting, solvent and spray drying methods. The SDs showedrapid and increased dissolution rates to about40%within10min. Theconcentrations and types of carriers and preparation methods, however, hadno effect regardless of the structural changes from a crystalline to amorphousform on the results, which were characterized by powder X-ray diffraction anddifferential scanning calorimetry.