| Solid dispersion is commonly used to increase solubility of poorly soluble drugs by converting a crystalline drug into a high energy solid state. In the present study, newly developed adsorption method is introduced to incorporate high energy Sulfathiazole-PVP K29/32 solid dispersion on to porous silicone dioxide (Syloid 244 FP). Different ratios of Sulfathiazole: PVP K29/32: Syloid 244FP were prepared (1:1:2, 1:1:3, 1:2:2) and categorized. Modulated differential scanning calorimeter (MDSC), X-ray diffraction, Fourier Transform Infrared Spectroscopy (FTIR) and dissolution studies were conducted to characterize the ternary systems. Lack of crystallinity was observed in internal and external systems suggesting loss of crystallinity, while physical mixture showed a characteristic peak of sulfathiazole. USP apparatus II was used to measure the dissolution rate of systems at 75 rpm in different media. The dissolution rate of all systems were compared. The dissolution rate of the optimum ratio (1:2:2) containing internal porous ternary dispersion system was found to be 3 times higher than the external and physical systems. Incorporation of porous silicon dioxide into solid dispersion acted as a carrier to disperse the complex and increase dissolution rate. |
