The Relationship Between Iron Status And Cadmium Injury In The Population Of Environmental Cadmium Exposure

Objective:To investigate the current situation of cadmium pollution in artisanal zinc-smelting area, and explore the relationship between iron status and cadmium injury. Method:Selected Magu town as a cadmium polluted area and Kele town as a control area. The samples of soil, eight kinds of common crops, four kinds of animal offal, and domestic water in polluted and control area were collected, and then measure the contents of cadmium in all samples.54persons from Magu town and40persons from Kele town were extracted and investigated about habits and customs by questionnaires, and collected blood and urine samples. Indicators, including UCd, BCd, AKP, ALT, DBIL, IBIL, TBIL, UALB, UTP, Uβ2-MG, UNAG, SFe, HB, SF were measured to analyze the relationship between iron status and cadmium injury. Results:The contents of cadmium in soil, domestic water, eight kinds of common crops and three kinds of animal offal in polluted area are higher than control area (P<0.05). The contents of cadmium in the soil of arable land which were artisanal zinc-smelting area before is higher than the other arable land (P<0.05). The level of UCd, IBIL, TBIL, UNAG, SFe, SF in exposure group are higher than control group (P<0.05), and other indicators have no significantly difference between the two groups (P>0.05). The level of DBIL, IBIL, TBIL, UNAG are higher as UCd increased and have positive correlation (P<0.05), so there is obvious dose-effect relationship between them. AKP and UNAG are higher as SF increased (P<0.05). All surveyed people were divided into two groups according to the level of SF, and the excess rate of UCd, AKP, UNAG in the high level of SF group are higher than low level group (P<0.05). SF have only positive correlation with AKP and ALT (P<0.01). Conclusion:1. The background level of soil cadmium in surveyed area was higher than control area, and the level of cadmium was aggravated by artisanal zinc-smelting. The contents of cadmium in crop and poultry offal which were locally produced were higher than control area, and caused a certain degree of liver, kidney damage to residents through the way non-cadmium-rice.2. There seems a relationship between higher iron status and cadmium injury in the people with higher levels of iron and cadmium uptake and accumulation, but according to the existing survey is difficult to conclude and further research is needed.