Optimization And Transformation Of Dazens Condensation And Salting Unit In Ibuprocen Devices

Ibuprofen is a non-steroidal anti-inflammatory drug. It is often used to easearthritis, menstrual pain, fever and other symptoms, especially for inflammation-induced pain. It is one of the World Health Organization designated essential drugs.Currently ibuprofen is mainly produced by Boots method in China. The manufacturesteps include Friedel-Crafts acylation reaction, Darzens-condensation,rearrangement reactions and Hydrolysis reaction. In the production of ibuprofen, thereaction time of Darzens condensation is long, greatly restricting the yield ofibuprofen. In addition, in the process of Darzens condensation, great amount ofneopentyl glycol is consumed to convert to large number of wastewater with2,2-two methyl3-chlorine alcohol.This paper studies the method to shorten reaction time by changing azeotropicagent. The types and dosage of azeotropic agent, ketone and alcohol molar ratio, andreaction time on the Darzens-condensation reaction are determined. The dynamicsare also established.Using petroleum ether as azeotropic agent, the reaction time to reach95%ketalcontent in products were420min in the original process. Using heptane asazeotropic agent, the reaction time to reach95%ketal content in products were290min under the optimal conditions for the condensation reaction: the amount ofheptanes is2.45times the volume of the solution of chlordecone, chlordecone andneopentyl glycol molar ratio of1:1.4, catalyst for the28%dilute sulfuric acid. Thereaction time can be reduced by31%.According to the results of pilot plant for cyclo-etherification of2,2-two methyl3-chlorine alcohol and hydrolysis reaction to produce neopentyl glycol, the industrial experiments were carried out. The residue of cyclo-etherificationcontaining a large number of oil and solid sodium chloride mixture were dealt withsolid-liquid separation technique.The optimal conditions for solid-liquid separation are as follows: demulsifierdosage60μL/L solution, pH1, temperature60℃, stirring speed100r/min. Underthese conditions the sodium chloride touches no greasy feeling after filtration. Thepilot were succeeded according to the experimental results and the industrial designof the treatment plant for the residue were determined.