Study On The Modification Of Elastin Via Self-assembly By Gelatin/Chitosan(Sodium Alginate)

Based on the good properties of elastin and the series advantages of layer-by-layer self-assembly technology in the surface modification of biomaterials. In this paper, first of all, elastin was modified via layer-by-layer self-assembly of chitosan(CS)/Type B gelatin and Type A gelatin/NaAlg respectively. Secondly, elastin was degraded partly and prepared into 3D scaffolds, and the modification of the elastin scaffolds was also explored.1. CS/Type B gelatin multilayer films were constructed on the elastin membranes. The advancing contact angle data revealed the hydrophilicity of the elastin membranes was greatly improved after assembly. The tensile test data showed the mechanical properties of elastin membranes had not changed after the modification.2. Elastin membranes were modified via layer-by-layer self-assembly of Type A gelatin/NaAlg. The advancing contact angle data revealed the hydrophilicity of the elastin membranes was greatly improved after assembly. The tensile test data showed the mechanical properties of elastin membranes had not changed after the modification.3. Elastin 3D scaffolds with good porosity were prepared. The pore diameter of the scaffolds prepared are very big. Furthermore, the elastin scaffolds were modified via layer-by-layer self-assembly of CS/Type B gelatin and Type A gelatin/NaAlg, and Scaffold porosity slightly decreased by the results of modification.