Studies On Chemical Constituents Of Alpinia Oxyphylla Miq.

Fructus Alpinia oxyphyllae is the dry fruit of Alpinia oxyphylla Miq., whichbelongs to the genus Alpinia in family Zingiberaceae, is mainly distributed in Hainan,Guangdong, Guangxi and other provinces in China. It has been widely used as a tonic,antidiarrbea, anti-salivation, aphrodisiac and antipolyuria traditional Chinesemedicines. Pharmacological studies have indicated that the extracts of A. oxyphyllaMiq. possess cardiac function, antioxidant, antiinflammatory, anticancer andneuroprotective activities. In searching for bioactive constituents, we hadsystematically investigated the chemical constituents of A. oxyphylla.The chemical constituents of Alpinia oxyphylla Miq. were studied by multiplechromatogrgaphical techniques, such as silica gel, sephadex LH-20, HPLC. Twenty–four compounds were isolated and Twenty–two of them were identified by means ofspectroscopic methods and physical and chemical data:(5S,7R,10R)-5-hydroxy-nore-udesma-2-dien-3,11-dione (AOM-1),(10R)-13-noreudesma-4,6-dien-3,11-dione(AOM-2),(5S,8R,10R)-2-oxoeudesma-1,7(11)-dien-12,8-olide (AOM-3),7-epi-teucr-enone (AOM-4), oxyphyllenone A (AOM-5), oxyphyllenone B (AOM-6),oxyphyllanene F (AOM-7),(11S)-nootkatone-11,12-diol (AOM-8), nootkatone(AOM-9), eremophila-1(10),11(12)-diene-2,9-dione (AOM-10), β-nootkatol(AOM-11), oxyphyllendiol A (AOM-12), oxyphyllendiol B (AOM-13), oxyphylloneG (AOM-14),4S-isoprophy-6-methyl-1-tetralone (AOM-15), vanillic acid(AOM-16),3,5-dihydroxy-4-methoxybenzoic acid (AOM-17), yakuchinone A(AOM-18), tectochrysin (AOM-19), izalpinia (AOM-20), β-sitosterol (AOM-21),daucosterol (AOM-22) respectively. Compounds AOM-1~AOM-3were three newsesquiterpenoids, and compounds AOM-7,8,10,15~17were isolated from this plantfor the first time.