| Background and Objective Atrial fibrillation has become a cardiovascular epidemic.Non-valvular atrial fibrillation initiates cerebral embolism easily, showing highincidence morbidity and mortality trends. It is compacted that screening high-riskpatients of non-valvular atrial fibrillation with cerebral embolism, lead to omissionlikely in clinical work. It is a higher cost of brain CT or MRI as diagnostic tool thatcause economic burden on patients.This review emphasizes on looking for a simple,affordable way to screening non-valvular fibrillation with cerebral embolism, whichcan treat patients earlier, faster and more accurate in order to reduce the incidence ofmorbidity. In recent years, many studies shown that inflammation is involved in theoccurrence, development, and maintenance of atrial fibrillation, but the relationship isunclear which between inflammation and non-valvular atrial fibrillation with cerebralembolism. This paper observes different levels of serum CRP of patients who AFcombine with or without cerebral embolism, and investigates clinical value of CRP toassess the risk of AF combined with cerebral embolism. In addition, this paperobserves the relationship between CRP and D-dimer in patients of non-valvular atrialfibrillation with cerebral embolism, and investigates D-dimer levels whether or notprovide laboratory evidence for the clinical diagnosis and treatment in non-valvularatrial fibrillation with cerebral embolism caused by elevated CRP.Methods According to non-valvula atrial fibrillation with or without cerebralembolism,88patients have been divided into two groups, and50healthy volunteershave been enrolled as control group. The levels of serum CRP and plasma D-dimerhave been examined in all subjects. All the data have been analyzed by statisticssoftware SPSS17.0. Normal distribution measurement data have been shown asmeans±standard deviation (X±S). The F Test has been applied to each of two groups.The χ~2test has been applied to compare the positive rate of group, and the relative risk (OR) has been calculated. The inspection standard is alpha＝0.05.Results The serum CRP (5.21±1.64)mg/ml in group of AF with cerebral embolismare obviously higher without cerebral embolism (1.96±1.12)mg/ml and control group(1.23±1.66)mg/ml. There are statistical significance among three groups (P<0.01).CRP>4.64mg/L as positive standard, the positive cases are35, and the positive rate is71.43%in NVAF with cerebral embolism. But the positive cases are6, and thepositive rate is15.38%in NVAF without cerebral embolism. The positive rate isstatistically significance (P<0.01). Compared with AF without high level of CRP,there is13.75times higher risk in AF with high level. With CRP levels′increasing，theD-dimer levels aslo rises in patients with NVAF. The results of correlation analysis ofserum CRP and plasma D-dimer levels has been showed a significant positivecorrelation to patients of non-valvular atrial fibrillation (r=0.840, P<0.01).Conclusion The rise of CRP in patients with atrial fibrillation prompts thatinflammatory response has been involved in the incidence of atrial fibrillation,develop and maintain mechanisms, and aggravate their conditions.Elevated CRP innon-valvular atrial fibrillation forms the cerebral embolism easily. Higher serum CRPis a reliable predictor of AF combined with cerebral embolism, and objectivelyreflected by the D-dimer laboratory indicators.The levels of serum CRP and plasmaD-dimer are conducive to clinical diagnosis, treatment and prognosis of clinicalvalue. |
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