The Research Of Transrectal Contrast-enhanced Ultrasonography Of Prostate Disease With Elevation Of Serum Prostate-antigen

Objective: To investigate the characteristic and diagnostic value of transrectalcontrast-enhanced ultrasonography in prostatic disease with elevation of SerumProstate-specific antigen.Materials and Methods:34patients with different serum prostate-specific antigenlevels and no positive transrectal color Doppler ultrasonography findings wereexamined by transrectal contrast enhanced ultrasonography and then identifiedpathologically by6-core systematic prostate biopsy under the transrectal ultrasoundguidance.11patients were malignant disease and23patients were benign. Observethe perfusion feature and the characteristic of the acoustic images during the contrastenhanced ultrasonography. Replayed the dynamic image of the contrast-enhancedultrasonography and analysed the ultrasound visualization images feature, protractedtime-intension curve and got the parameters of AT, TTP, PI, WoR, and T1/2by QLABof the34patients.Result:1. Compared with benign tissue group the enhancement features of PCa tissuegroup were rapid reach AT, TTP, T1/2, and the AT, TTP, T1/2had statisticallydifference between benign tissue group and PCa tissue group (P=0.000).2.Compared with benign patient group the enhancement features of PCa patient groupwere rapid reach AT, TTP, T1/2, and the AT, TTP, T1/2had statistically differencebetween benign patient group and PCa patient group (P=0.000).3. In PCa patients,compared with benign tissue group the enhancement features of PCa tissue groupwere rapid reach AT, TTP and the AT, TTP had statistically difference betweenbenign tissue group and PCa tissue group (P=0.018, P=0.017).4. In benign tissuesAT and TTP had no statistically difference between different serum PSA levels, andPI, WoR and T1/2had statistically difference between different serum PSA levels(P=0.000).5. In PCa tissues, T1/2had no statistically difference between differentserum PSA levels, and AT, TTP, PI, and WoR had statistically difference betweendifferent serum PSA levels (P respective=0.000,0.000,0.011,0.002).6. ProtractROC curve of AT, area under the curve is0.908,95%confidence interval is0.865～ 0.950, Std. Error is0.022, area under the curve0.908>0.9, reckon AT has highvalue of diagnosis.7. Protract ROC curve of TTP, area under the curve is0.933,95%confidence interval is0.897～0.968, Std. Error is0.018, area under the curve0.933>0.9, reckon TTP has high value of diagnosis.Conclusion:1. Transrectal contrast enhanced ultrasonography can reflect real-timeand dynamic prostate flow perfusion status. It can also quantification the perfusionfeature of the prostate by analyse different parameters of time-intension curve.Transrectal contrast enhanced ultrasonography can help to the diagnosis anddifferential diagnosis of prostate disease.2. AT and TTP have high value of diagnosis.