The Expression Of T-cadherin And β-catenin In Hepatocellularcarcinoma And Its Correlation With Recurrence And Metastasis

Objective：To investigate the distribution of T-cadherin in human hepatocellularcarcinoma (HCC) and its correlation with invasion and metastasis.Methods：The Immunohistochemical staining (Elivison TM plus method) wasused to detect the expression of T-cadherin in the60cases of hepatocellularcarcinoma （HCC）and their adjacent non-tumoral tissues at protein level; alsoRT-PCR was employed to detect the expression of T-cadherin at mRNA level.Results：(1) The abnormal expression score46.5%（28/60）of T-cadherin andtheir adjacent normal tissues6.67%（4/60） are statistically significant difference（χ2=24.545p＜0.001）.(2) The disorder expression of T-cadherin inwell-and-moderately-differentiated HCC was30%(6/20), no statistically significant(χ2=0.114p=0.736) with the poorly-and-moderately differentiated HCC35%(7/20).However, The disorder expression of T-cadherin in HCC with transfer (including theliver, extrahepatic or portal vein invasion) was75%(15/20), was statisticallysignificant compare with the HCC32.5%(13/40) without metastasis (χ2=9.676p=0.002).Conclusions：The abnormal expression rate increased of T-cadherin in HCC,was also related to invasion and metastasis in HCC, so they may be considered as theuseful prognostic targets and study on drug targets. Objective：To study the expression of β-catenin in hepatocellular carcinomaand the correlation with recurrence, metastasis of postoperative primaryhepatocellular carcinoma.Methods：Immunohistochemical staining (Elivison method) was used to detect the expression of β-catenin（paired observation the tumoral and their adjacentnon-tumoral tissues, the TNM was same before the surgery）in the postoperativepatients with the recurrence and/either metastasis and without the recurrence and/ormetastasis,also compared with the clinical pathology characteristic1year latter.Results：(1) The expression of β-catenin in the tumors appear weakly positive whilethe disorder expression was60%（24/40）and higher than the adjacent normaltissues15%(6/40), there was a significant difference between the two groups (χ2=17.28p＜0.001); The expression of β-catenin in the adjacent normal tissues of thetwo group with cirrhosis and without was no difference（χ2=0.388p=0.533）；(2)The disorder expression of β-catenin in primary hepatocellular carcinoma (withrecurrence and metastasis) was80.0%（16/20）,statistically significant difference(χ2=6.667p=0.010）with primary hepatocellular carcinoma40.0%（8/20）(withoutrecurrence and metastasis);(3) The abnormal expression of β-catenin is notcorrelated to age、liver cirrhosis、tumor size and differentiation grade, but associatedwith the recurrence and metastasis of primary hepatocellular carcinomaConclusions：The abnormal expression of β-catenin is associated with thedevelopment of HCC and the recurrenc、 metastasis of postoperative primaryhepatocellular carcinoma. The abnormal expression of β-catenin may be consideredas a useful prognostic target to predict overall survival.