Basic Research On The Construction Of Real-Time Monitoring Models In Laser Induced Interstitial Thermotherapy

Laser-induced interstitial thermotherapy (LITT) is a new technology for tumor treatment. Itcauses the tissue necrosis through the interaction of light and heat effects. LITT is still far fromperfect, for instance, lacking in acquiring optical properties of biological tissue, difficult to getreal-time temperature in space, hard to evaluate the efficacy with quantized factors and so on, whichmake against to the safety and accuracy of the operation. This paper raises a concrete proposal tosettle the problems above. Collecting the optical properties by using near infrared spectroscopy andcreating volume models of effective lesions from simulation and experiments, which was got rid ofblindness and low accuracy, provide references for the application of laser-induced interstitialthermotherapy.Firstly, this paper simulates the temperature distribution of tissue with LITT by using finiteelement analysis software according to the application of finite element method to bio-heat transfer.Secondly, the author deduced the volume model based on the simulation. The temperature distributionmodel decided instantaneous temperature at any position of the tissue while the volume modeldecided the size of effective lesions at any laser power and time. At the same time, a large number ofexperiments are made to validate the proposal. Experimental volume model and reduced scatteringcoefficient (μ′s) model are presented resulted from the outcome. The former is to prove the efficiencyof the simulation while the latter is used to be the real-time monitoring model which can evaluate thelevel of ablation.The creativeness of this study is as follows:(1) present the simulation models based on finiteelement method, including temperature distribution model and volume model of effective lesion,(2)create the experimental volume model and reduced scattering coefficient (μs′) model, validate theefficiency of simulation and lay the groundwork for treatment of LITT,(3) advance the idea ofefficacy assessment, design the real-time monitoring method by usingμs′, provide references for theapplication of LITT.