Primary Study Of Related Risk Factor About Adult Renal Post-transplantation Diabetes Mellitus

Objective: To understand the incidence of renal post-transplantationdiabetes mellitus（PTDM）in our hospital,and to compare it with othercorrelated studies domestically and overeseas. To screen related risk factorsand to provide datas for individual therapy after transplantation.Methods: The clinical data of patients, who received allogeneic renaltransplant surgery from October 2007 to April 2011 in Kidney TransplantationCenter of Sichuan Province People’S Hospital,were collected.There were 155patients, 108 of them were male, 47 of them were female.Total 128 patientswere enrolled in the study according to the diagnosis standards and definitionsof PTDM.The patients were divided into two groups. 51 patients wereassigned to the group of PTDM and 77 patients were assigned to the group ofnone-PTDM(N-PTDM). Data of patients including: age, body massindex(BMI), alcohol and tobacco history, family history, cholesterol,triglyceride, blood pressure, uric acid, whether if dialysis, the dialysis time,postoperative immunosuppressive monitoring and acute rejection, etc.werecollected.The unconditional logistic regression mode for simple factors ormulti-factors,chi-square test,and t test were used. There is statisticalsignificance if P <0.05. All the statistical analysis were performed in SPSS17.0 statistical software.Results: Among 128 cases,88 cases were male, 40 cases were female,with an average age of (36.44±9.78) years old. Donor kidney resourcesincluding 62 cases of cadaveric kidney and 66 cases of living kidney,were involved。Our study showed that the PTDM incidence of renal transplantation was39.84% in our hospital .There were no statistical differences between thetwo groups in age, sex, BMI, blood pressure, blood lipids, blood uric acid andother basic treatment before operation(P > 0.05).Logistic regression analysis of single factor showed that the age, sex,BMI, blood pressure, blood fat , blood uric acid, and other factors had nocorrelation with PTDM(P>0.05).Whether if dialysis and the dialysis time alsohadn’t correlation with PTDM(P>0.05).The Immunosuppression protocolsusing FK506 primarily and the acute rejection were significantly associatedwith PTDM(P<0.05).Multi-factors unconditional Logistic stepwise regression analysis showsthat the Immunosuppression protocols using FK506 primarily and the acuterejection were significantly associated with PTDM(P<0.05).Conclusion: First,the incidence of PTDM was 39.84%in our hospital.The result was similar with other domestic and foreign studies.Second, the immunosuppression protocols using FK506 primarily andthe acute rejection were independent risk factors of PTDM.Third,the applying of dialysis and its duration had no correlation withPTDM.Finally, BMI, age, hypertension, blood lipids, donor sources and HCVinfection had no correlation with PTDM...