Correlation Analysis Of Risk Factors For Diabetes Mellitus After Renal Transplantation

Objective:To analyze the risk factors of Post-Transplant Diabetes Mellitus(PTDM)and their correlation.Method:1.Collected the case data of patients who underwent kidney transplantation for the first time in the organ transplant center of Sichuan Provincial People’s Hospital from January 2006 to January 2018,a total of 1441 cases,including 119 cases with fasting blood glucose≥7.0mmol/L within 1 year after operation,and included In the study,after hypoglycemic therapy,patients were divided into two groups at 1 year after operation.Patients without hypoglycemic therapy and fasting blood glucose<7.0mmol/L were included in the non-PTDM group(37 cases)with fasting blood glucose≥7.0mmol/L or fasting blood glucose<7.0mmol/L and patients undergoing hypoglycemic therapy were included in the PTDM group(82 cases).Calculated and analyzed whether there is statistical difference in the age,gender,history of tobacco and alcohol,family history,history of hypertension,polycystic kidney disease,dialysis time,history of hepatitis C virus(HCV)infection,preoperative body mass index(BMI),and uric acid(UA),total cholesterol(TC),triglyceride(TG),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C)levels,postoperative calcineurin inhibitors(CNIs)blood drug abnormal rise history,CNIs use regimen,acute rejection and glucocorticoid dose at 1 year after the operation of patients between the two groups.2.All risk factors were included in multi-factor binary logistic regression,and the correlation between PTDM and each risk factor was analyzed.Result:1.Compared with the non-PTDM group,the single factor analysis showed that the age,preoperative BMI,UA,TC,and LDL-C levels of the PTDM group were significantly increased(P<0.05),while the HDL-C levels were significantly decreased(P<0.05).The dialysis of the PTDM group For a longer period of time,there were more patients with a history of HCV infection and a history of tobacco and alcohol in the PTDM group,and the difference was statistically significant(P<0.05).Compared with the non-PTDM group,the PTDM group had more patients with a history of abnormal rise blood concentrations of CNIs,the use of tacrolimus(FK506),and a history of acute rejection.At 1 year after operation,the glucocorticoid dose was higher in the PTDM group,with a difference Statistical significance(P<0.05).2.The results of multivariate analysis showed that the older the patient,the higher the level of LDL-C before surgery,the duration of dialysis≥1 year,the history of abnormal rise blood concentrations of CNIs,the use of FK506,and the history of acute rejection can significantly increase the risk of PTDM(P<0.05),the OR values were all greater than 1.Conclusion:One year after the operation,the incidence of PTDM in our hospital was 3.32%.Older patients,higher LDL-C levels before surgery,and dialysis duration≥1 year were independent risk factors for PTDM.Postoperative history of abnormal rise blood concentrations of CNIs,use of FK506,and history of acute rejection were independent risk factors for PTDM.