The Value Of Tumor Markers And18F-FDG PET/CT For Prediction Of Disease Relapse And Recurrence With Breast Cancer

Objective To evaluate the value of tumor markers and18F-FDG PET/CT for prediction of disease relapse and recurrence with breast cancer.Methods We collected75patients of breast cancer who have already treated with primary surgery and neoadjuvant therapy and/or adjuvant treatment. All the patients were underwent PET/CT scan after more than3months after the primary treatment was ended, and41patients performed the exams of CEA、CA153and spiral CT in the same time. The intervals between PET/CT scan and the exam of tumor marker was within3days, and the spiral CT was before PET/CT.The final diagnosis was established by invasive and noninvasive follow-up.and in this group we followed up for6-12months.Results1.The increased degree of CEA and CA153in the group of recurrences and metastases was higher than the group of non-recurrences and metastases, the difference was statistically significant (P<0.05). The tumor markers of multiple metastasis group increased significantly higher than the group of single metastasis, the difference between the tow groups were statistically significant (P<0.05).2The sensitivity、accuracy and negative predictive values of PET/CT were higher than PET and spiral CT, and the difference between sensitivity、accuracy was statistically significant (P<0.05).3. The tumor markers and PET/CT have good correlation, and the correlation coefficient Y=0.69. In the19patients of tumor markers elevated,18F-FDG PET/CT imaging was positive in18cases, negative in1case, the positive rate was18/19(94.7%).22patients of the tumor markers within normal levels, the imaging of18F-FDG PET/CT was positive in6cases and negative in16cases, the positive rate was6/22(27.3%). The difference between the two groups is a significant statistically significant (P<0.05). The PET/CT positive rate has a rising trend following the rising degree of tumor markers.4. In our study the treatment plan of the patient was amended in29cases, the rate was70.7%.5. In our study, we found that the patients of breast cancer were more likely to have lymph node and bone metastases. The position of lymph node metastasis is more common in the neck. The metastasis rate of bone was higher with the increasing of the follow-up years.6.16patients have dual-phase imaging, and11cases was diagnosed as metastasis, the SUV values were elevated in different degrees.Conclusions The tumor markers and PET/CT have good correlation, there was an important clinical value for the patients to perform PET/CT scan when the the tumor marker was beyond the normal range.2. The increased degree of tumor markers has positive correlation with the severity of the disease and the positive imaging of the PET/CT. The positive rate of PET/CT imaging was more higher when the tumor marker elevated more obvious and the lesions had more greater range.