Real-time Organization Elastography Quantitative Analysis For Early Diagnosis Of Hepatic Fibrosis Research Value

Background and objectiveLiver fibrosis is to point to by all kinds of pathogenic factor connective tissue inside liver caused by abnormal growths, lead to liver inside diffuse the extracellular matrix, the pathological process of excessive precipitation. It is not an independent disease, but many chronic liver disease caused by all. The most common disease of the liver fibrosis with Chronic viral Hepatitis B (Chronic Hepatitis B, CHB), CHB generally associated with the degree differs liver fibrosis. Early Liver fibrosis (S1, S2 of period of time) to control the diagnosis of CHB illness development for Liver cirrhosis, Liver cell Carcinoma (Hepatocellular Carcinoma, HCC) irreversible adverse outcome is of great significance, now commonly used diagnosis method mainly have Liver biopsy (Liver Biospy, LB), fibrosis biochemistry detection and Liver fibrosis four examination, but because the traumatic big, false negative high, difficult to observe the dynamic factors limit, can not meet all clinical needs.Real-time organization elastic imaging (Real-time Tissue Elastography, RTE) technology as a noninvasive, fast and accurate diagnostic method, can effective evaluation early fibrosis, for clinical provide lots of useful information.This study applies based on traditional RET the quantitative analysis on technology of Liver Fibrosis early testing aimed at assessing RET quantitative analysis in the early diagnosis of Liver Fibrosis (S1, S2 period of the application value, this paper discusses the Index of Liver Fibrosis (Liver Fibrosis Index, LF Index) reference Index.Materials and MethodsChoose in December 2010 in October to 2011 in our hospital do ultrasound-guided lier biopsies of 60 patients with CHB patients (S1, S2 period) the same period and the healthy check-up 50patients (control group). S1 period group 28 cases, age 25～56 years old, an average of 40.3±14.6 years old, male 15 cases, female 13 cases. S2 period group 32 examples, age 28～57 years old, an average of 42.2±13.9 years old, male 18 cases, female 14 cases. Among the 100 cases, age 24～60 years old, an average of 41.8±16.3 years old, male 25 cases, female 25 cases and control were no history of hepatitis b virus (HBV) infection, and the liver function is normal.The Hitachi HV Preirus color doppler ultrasound diagnostic instrument, the application of quantitative analysis technology RET measuring the interested Region (Region of Interest, ROI) inside the parameters and calculation LF Index.ResultsMeasurement data is normal distribution with "mean±standard deviation" said, the single factor analysis of variance and SNK-q inspection comparison group LF Index difference, inspection standardsα=0.05, P<0.05, Index of liver fibrosis in comparison between groups are significantly different. Quantitative calculation normal person, S1, S2 period of the LF Index reference Index, and experts similar results.ConclusionRET quantitative analysis LF Index as early diagnosis of hepatic fibrosis means for the clinical provides more information of value, and, to some extent, the more accurate judgement of liver fibrosis stage and can be used as a quantitative analysis of the early liver fibrosis (S1, S2 period) reference Index, help to liver fibrosis assessment.