| The biological material is uses in the Body tissue and organ’s diagnosis, the repair or promotes its function a kind of high-tech material, repairing the living tissue natural or the artificial material, already widely used in treating each kind of athletic injury,its development has experienced three stages. The silicate biological activity glass is the second generation of biological material, according to contains the silicon quantity to be different, divides into several kinds,45S5most has the representation.In the clinical each kind of surgery, the biggest difficult problem is the bacterial infection. In does not increase the side effect under the premise, if the silicate biological activity glass has antibacterial, the biological material will have the very big progress in the clinical practice, will have the practical practice significance. The expert devotes to the silicate biological activity glass antibacterial research and the application, has made the meaningful breakthrough, confirmed its antibacterial characteristic.The literature reported that the influence silicate biological activity glass antibacterial possible factor to have the powder body solution environment pH value, powder body pellet particle size, the powder body to bacterium’s adherence,the liquid environment ion concentration and the osmotic pressure and so on, but the ion concentration and the osmotic pressure factor has not obtained further confirmation. This article takes the liquid environment ion concentration and the osmotic pressure the research target, the discussion ion concentration and the osmotic pressure in the biological activity glass45S5antibacterial function.Methods:Determines the45S5powder body different density and the different raise time leaching solution osmotic pressure, according to45S5osmotic pressure scope configuration wide range osmotic pressure neutral solution, after bacilliculture, the analytical data draws the conclusion. Determination powder body leaching solution sodium calcium density, configuration wide range ion concentration neutral solution, after bacilliculture, the analytical data draws the conclusion.Results:1.45S5powder body leaching solution osmotic pressure value in420-476mosm/kg scopes. Soaks differently proposes the time not to have the significance difference regarding the osmotic pressure influence, the different powder body density has the significance difference to the osmotic pressure.2. The osmotic pressure is in200-600mosm/kg scope neutral solution, the bacterium grows changes not obviously.3. The sodium density is4.41-12.34mg/ml, the calcium density is in0.009-0.281mg/ml scope neutral solution, the bacterium grows changes not obviously.Conclusion:1.The osmotic pressure and the powder concentration of the bioactive glass powder extract into a positive correlation, no significant correlation with the incubation time.2. Growth of bacteria in a neutral solution of200-600mosm/kg no significant changes in osmotic pressure, that is within this range no significant role in the bioactive glass antibacterial.3.bacteria in the Na+concentration is4.41-12.34mg/ml Ca2+concentration of0.009-0.281mg/ml liquid environment can survive, this range of Na+and Ca2+concentration in the bioactive glass antibacterial role. |
