The Therapeutic Effect Of Himalayan Teasel Root Radix Seu Caulis Celastri Orbiculati Scorpion Decoction With Semen Coicis Carassius Auratus Decoction On Treating Rheumatoid Arthrittis

Object i veTo evaluate the therapeutic effect of Himalayan Teasel Root Radix seu Caul is Celastri Orbiculati Scorpion decoction and Semen Coicis Carassius Auratus decoction in the therapy of rheumatoid arthritis (RA).MethodSixty RA patients fulfilling including criteria were randomly dividing into therapeutic group and control group. Patients in therapeutic group were administrated decoctions as follow:(1) to decoct Radix seu Caul is Celastri Orbiculati45g and Scorpion5g for3.5hours, then plus Himalayan Teasel Root15g and decoct for0.5hours, this decoction was taken once per day;(2) to decoct Semen Coicis50g, Carassius Auratus500g, porcine vertebral column500g from4bowls of water to1bowl of decoction, this decoction was taken twice per day, half bowl of decoction per time. Patients in control group were just administrated decoction (1) of therapeutic group. Course of treatment in both groups was6weeks. Total number of articular tenderness, articular tenderness index, number of joint swelling, joint swelling index, time of morning stiffness, average hand strength, VAS score, HAQ index, RF, CRP, ESR, were observed after6weeks after therapy. Blood routine test, hepatic renal test, and side effects were monitored during therapy.ResuleTotal effective rate was86.7%and76.7%in therapeutic group and control group respectively. Total effective rate in therapeutic group was significantly higher than control group (P<0.05).DAS28score in both therapeutic group and control group were improved significantly after therapy (P<0.05). DAS28score in therapeutic group was significantly higher than control group after therapy (P<0.05). Both combinative therapy and Himalayan Teasel Root Radix seu Caul is Celastri Orbiculati Scorpion decoction can decrease activity in acute phase of RA. Combinative therapy had better effect than Himalayan Teasel Root Radix seu Caulis Celastri Orbiculati Scorpion decoction alone.Total number of articular tenderness, articular tenderness index, number of joint swelling, joint swelling index, time of morning stiffness, average hand strength, VAS score and HAQ index significantly improved after therapy in therapeutic group (P<0.05). Total number of articular tenderness, articular tenderness index, number of joint swelling, joint swelling index and VAS score in control group significantly improved after therapy (P<0.05). Time of morning stiffness, average hand strength and HAQ index didn’t have significant improvement after therapy in control group. Total number of articular tenderness, articular tenderness index, number of joint swelling, joint swelling index in therapeutic group improved significantly than control group after therapy (P<0.05). There was no statistical significance in VAS score between two groups.RF, CRP, ESR levels in both groups decreased after therapy. CRP levels in therapeutic group were significantly decreased in therapeutic group than control group.There were3patients in therapeutic group and4patients in control group had side effect during therapy. In therapeutic group, one patient had digestive symptoms of nausea and vomiting, epigastic upset and eructation, abdominal distension and diarrhea, these symptoms were relieved after antacid agent administration; one patient had increased transaminase level, and relieved after hepatic protective agent administration; one female patient had amenorrhea. In control group, one patient had singultous and recovered automatically; one patient had increased transaminase level, and relieved after hepatic protective agent administration; two female patients had amenorrhea. All patients did not have server side effect.Conclusion Himalayan Teasel Root Radix seu Caulis Celastri Orbiculati Scorpion decoction and combinative therapy with Semen Coicis Carassius Auratus decoction had pronounced therapeutic effect to RA. Combinative therapy has better effect to RA and can be applied to clinical treatment in the mode of Chinese medicine combine with dietary therapy. Side effects between two groups had no statistically significant difference.