| Objective：To investigate the reference range of Tp-Te interval in thenormal population.Methods：Totally 110 consenting subjects aged from 17 to 80 wererecruited in our study. Synchronous 12-lead standard electrocardiograms(ECG) were assayed in all the subjects, the average Tp-Te intervals weremeasured in three consecutive cardiac cycles. All the data were processed inExcel for further analysis.Results：The maximum Tp-Te intervals were more common in chestleads in approximately 88.56% of the subjects, among whom, 30.20% withthe maximum values in lead V2; On the contrary, the minimum Tp-Teintervals were more common in limb leads in 89.01% of the healthpopulation, in whom 34.01% with the minimum value in lead AVL. In the 12leads, the maximum Tp-Te interval was (0.102±0.018)ms in lead V2(95%CI 0.127, 0.138), while the minimum one was (0.061±0.014) ms inlead AVL (95%CI 0.081,0.090). In limb leads, the maximum and minimumTp-Te intervals were leadⅡ(0.079±0.015) ms and lead AVL (0.061±0.014)ms respectively, while in chest leads, the maximum and minimum Tp-Te intervals were lead V2 (0.102±0.018) ms and V6 (0.085±0.017) msrespectively.Conclusions：The Tp-Te intervals are vary in synchronous 12-lead ECGand the maximum values are more common in chest leads, especially thelead V2. Lead V2 is the preferred lead when measuring the Tp-Te interval. Abstract:Objective To study whether the Tp-Te intervals of lead V2 inpatients with dilated cardiomyopathy (DCM) were statistically different thanthat the normal, to investigate the relationship between Tp-Te intervals andcardiac function as well as the the ventricular remodeling. To explore theefficacy of clinical management on the Tp-Te intervals in DCM withdifferent stage of cardiac function.Methods:We retrospectively analyzed 238 inpatients’ECG who werediagnosed with DCM and were enrolled in cardiovascular department of theaffiliated hospital of North Sichuan Medical College from Jan 2009 to Dec2010, among whom, totally 92 subjects including 54 males and 38 femaleswith the mean age of 58.46 years old and the average 12.86 days ofhospitalization met the inclusion criteria. The Tp-Te intervals were assayedfor all the subjects on the first ECG after admission and the last ECG beforedischarge. The parameters of ultrasound cardiogram were simultaneouslyrecorded to calculate the heart weight index.Results:The Tp-Te intervals of lead V2 in patients with DCM were statistically longer than that of the normal with P＜0.01, and according to theheart function classification of NYHA, The Tp-Te intervals of DCM withstagedⅢandⅣcardiac functionwere longer than that of the normal toowith P＜0.01 both. When compared this indicator in the DCM with differentcardiac stage, those fell into the stageⅢwas statistically shorter than that ofthe classⅣ(P＜0.05). The Tp-Te intervals in DCM were positivelycorrelated with the heart weight index (r=0.65, P＜0.01) and the leftventricular end-diastolic diameter (LVEDD) (r=0.751, P＜0.01) butnegatively correlated with the left ventricular ejection fraction (LVEF)(r=-0.588, P＜0.01). For patients with DCM, there was no obviousdifference of Tp-Te intervals of lead V2 before and after the treatment, therewas no statistical difference of the Tp-Te intervals of lead V2 in patients withDCM and fell into the classⅢbefore and after the routine treatment（P＞0.05）while in patients fell into the classⅣ, there did exist the obviouschanges（P＜0.01).Conclusions The fact that:the Tp-Te intervals of lead V2 in patientswith DCM are obviously longer than that of the normal suggests that theventricular transmural dispersion of repolarization (TDR) is increased andwith higher risk for ventricular arrhythmia. Both heart failure andventricular remodeling can influence the Tp-Te intervals significantly through increasing the TDR. The clinical management is beneficial toTp-Te intervals in DCM with stagedⅣcardiac function. |
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