The Effects Of Immunomodulation On Ventricular Remodeling And Cardiac Function Of Dilated Cardiomyopathy Rats

Backgrounds:Congestive heart failure (CHF) is the end stage of many cardiovascular diseases, which is threatenning human health. Dilated cardiomyopathy (DCM), hypertension and ischemic cardiomyopathy are the common origin diseases. Although recently marked advance in pathogenesis and therapy methods have been made, the aggravation of CHF has not been fully interrupted. The readmission rate is still high and the prognosis remains fairly poor. Some data showed that five-year surival rate of patients with CHF was similar with malignant tumors. Although the pathogenesis of CHF has not been fully identified, more and more evidence indicates that, in addition to marked neuroendocrine disturbance, immune interference and inflammatory reaction play a crucial role in progression and development of CHF. It has evoked worldwide great interest in exploring potential anti-inflammatory therapies targeting immune activation in patients with CHF. The anti-inflammatory and immunomodulation effects of pentoxifylline (PTX) and methotrexate (MTX) has been demonstrated in many diseases such as rheumatoid arthritis. In addition, PTX also elicits the effects of anti-fibrosis and anti-apoptosis.