Cynomolgus Monkey Striatum¹⁸F-AV-133Image Feature In PET/CT Scan

Objective:Explore the cynomolgus monkey striatum18F-AV-133PET/CT imaging of the image feature.Methods-.Application of PET with the software were used to measure the seven cases of normal cynomolgus monkeys, five cases of unilateral striatal damage Parkinson’s disease (PD) model of cynomolgus monkeys, and10cases of bilateral striatal damage model of PD cynomolgus monkey PET/CTSUVmax of the bilateral striatum, frontal, bilateral temporal lobe, bilateral parietal, occipital lobe, bilateral cerebellum, bilateral scalp, bilateral skull and other imaging Figure8position, On this basis, the striatum is the target organ-oriented end of the surrounding brain tissue to the target/background as a semi-quantitative indicators, and used for statistical analysis.Results:1, normal cynomolgus monkey striatum the SUVmax the mean is8.08±1.40, mean SUVmax of the remaining seven positions (frontal, temporal lobe, parietal lobe, occipital lobe, cerebellum, scalp, skull) were3.73±0.61,3.83±0.53,2.79±0.39,2.60±0.43,2.78±0.60,0.85±0.13,2.16±0.34. position SUVmax mean significant difference (F=70.49, p=0.00), striatum SUVmax was significantly highin the remaining seven parts of the SUVmax.2, unilateral PD model of cynomolgus monkeys health striatum the SUVmax the mean5.69±1.09, ipsilateral striatum mean SUVmax of3.38±5.68. The risk of health on both sides of the striatum SUVmax mean significant difference (t=-5.85, P=0.00).3, bilateral striatal damage the PD monkey left, right striatum SUVmax mean:2.68±0.59,2.67±0.58, on both sides of whether the significant difference (t=0.50, P=0.63). PD model of bilateral striatal damage food cynomolgus monkey with normal cynomolgus monkeys with bilateral striatum/occipital, striatal/parietal lobe, striatum/frontal lobe, striatum/temporal lobe, like body/cerebellum, striatum/scalp, striatum/skull SUVmax pairwise comparisons bilateral There were significant differences (p=0.05).Conclusion:1, normal food the cynomolgus monkey striatal18F-AV-133PET/CT imaging of18F-AV-133imaging agent bilateral striatal uptake, with the frontal lobe, temporal lobe, parietal lobe, occipital lobe, cerebellumscalp, skull and other parts of the intake have a higher contrast in imaging agent;2, damage to the striatum (unilateral and bilateral) PD model of cynomolgus monkeys18F-AV-133of PET/CT imaging lesions of the striatum expressed as18F-AV-133imaging agent uptake than normal striatum significantly reduced.