The Correlation Between Recent Infection And Ischemic Stroke In Study And Discussion

Objective:we performed a case-control study to explore the correlation between recent infection and ischemic stroke and its role in cerebral ischemic injury,at the same time to explore its possible pathogenesis, and to provide new ideas for the prevention of ischemic stroke.Methods:According to the selected conditions, We examined120consecutive patients with acute ischemia stroke in the acute phase of our hospital neurology department were admitted and120patients hospitalized for nonvascular diseases as a control group.Within48hours admitted, we investigated the general conditions,the past medical history,with/without recent infection and the infection types of patients by using questionnaires respectively.To grade ischemic stroke patients according to etiological classification.At the time of admission and14days after admission,all patients were received a standardized neurologic examination as previously. To detect low density lipoprotein cholesterol (LDL-C), hyper-sensitivity C-reactive protein (hsCRP), total plasma homocysteine (tHCY), Fibrinogen (FIB), the D-dimer and other indicators.Data are given as mean±SD for continuous variables.Statistical analysis was performed with χ2analysis and t tests as appropriate.Logistic regression analysis was performed to identify all the clinical variables. All calculations were made with the SPSS17.0statistical package, and the difference was significant when P<0.05.Results:1. Hypertension, smoking, diabetes, history of the TIA, hsCRP,recent infection,LDL-C and tHCY represented significant differences between ischemic stroke group and control group(P<0.05). Hypertension, diabetes,LDL-C,tHCY and recent infection were more significant (P<0.01).2. To mean ischemic stroke as dependent variables(ischemic stroke=1;no ischemic stroke=0).8factors, such as smoking, hypertension, LDL-C, diabetes,history of the TIA,hsCRP, tHCY, recent infection were independent variables. The influence of their risk factors can be seen in this order:LDL-C(2.890)>hypertension(2.742)>recent infection(2.710)>diabetes (2.588)>smoking(1.895) by odds ratio(OR) value from logistic regression analysis.3. The frequency of infection was greater in ischemic stroke group for almost all types of infection.The distribution of different infection types was similar in both groups(P>0.05), with respiratory infections being more prevalent in both groups4. For rencent infection,the constitutes of subtypes of ischemic stroke was a significant difference in two groups(χ2=8.613,P<0.05).Patients with recent infection suffered more often from large-artery atherosclerosis type.5.Patients with reticent infection had a more severe neurological deficit on admission and14days after admission than those without infection (P<0.05).For patients with rencent infection, the NIHSS score was not a significant difference between admission and14days after admission(P>0.05). But in the group of patients without infection,we found differences in the severity of neurological deficits between admission and14days after admission (P<0.05).6.The level of fibrinogen was higher in patients with infection than in those without infection (P<0.05). The levels of D-dimer and WBC represented no differences between with infection and without infection(P>0.05).Conclusions:1.Recent infection may act as a trigger and increase the risk of ischemic stroke, especially in large-artery atherosclerosis type.Ischemic stroke patients with recent infection suffered more often from respiratory infection.2.Ischemic stroke with recent infection would lead to more severe neurological deficits and poor patient outcomes.3.The level of fibrinogen was higher in patients with infection,may be related to the pathogenesis.