The Relationship Of Inflammatory Pain And Learning And Memory In Rats

Objective1. To observe the effect of inflammatory pain on the rats’ learning and memory.2. If effected, to investigate the method of improving the rats’ learning and memory and thepossibility of clinical application.Methods1.Thirty SD rats weighting450g-650g were randomly divided into3groups: group Acontrol (n=10); group B inflammatory pain (n=10); group C analgesics (n=10).2. Group A was injected0.9%physiological saline200ul. Group B was injected volumefraction5%(50g/L formaldehyde)200ul in the upper lip (because the test is operated in water,so the non-wound–induced pain model is used to avoid the impact of wound infection). Basedon the group B, group C was injected Dynastat (5mg/Kg) to analgesia.3.24hours after the completion of the modeling, each group was conducted to have watermaze test, which had been for4days.Results1.Compared with the group A, the time of finding the platform in group B was significantlonger in the following four days（P<0.05）, it means that the learning and memory disabilityproduced.2.Compared with the group B, the time of finding the platform in group C was significantshorter in the four days（P<0.05）, it means that the learning and memory function wasrecovering.3.Compared with the group A, the time of finding the platform in group C was significantlonger in the2nd da（yP<0.05）, there was no significant difference between the two groups in therest3days. It means that the analgesic therapy can make the learning and memory functionreturn to the normal levels.4. As time goes by, the escape latency time of group B can decline to the level of the groupA in its first day.Conclusion1. Inflammatory pain can cause the decline of the rats’ learning and memory function.2. Inflammatory pain can lead the shorter disability of the rats’ learning and memoryfunction; as time goes by, the pain is disappearing, this condition has been improved.3. Analgesic therapy can improve or recover the rats’ learning and memory function. It is meaningful to prevent the occurrence of the postoperative cognitive dysfunction in clinical.