Comparative Efficacy Of Allisartan With Losartan Treatment Of Light To Moderate Essential Hypertension

Purpose：Through the Allisartan with losartan potassium controlled trials,observed Allisartan in patients with mild to moderate essential hypertensionantihypertensive effect.Method: Select age in the18-70years old, male or female, body massindex in18.5kg/m2~26kg/m2according to Chinese Hypertension PreventionGuide2005revised diagnostic criteria, a diagnosis of mild to moderate essentialhypertension in34patients as the research object, giving the drug for2weeksafter the cleaning period, mean sitting blood pressure (5seat resting after every2points per clock clock measuring volume three times systolic/diastolictension pressure, and flat are value) for140mmHg≤SBP <180mmHg and90mmHg≤DBP <110mmHg male or female in low risk patients with essentialhypertension, according to1:1divided randomly, respectively Allisartan groupinto the experimental group (group A), accept Allisartan240mg/D, losartanpotassium group as control group (group B),50mg/D treatment, subjects1times a day, half an hour before breakfast fasting oral, for12weeks. In thetreatment of2weeks,4weeks,8weeks,12weeks sitting blood pressuremeasurement for evaluation.Results:Allisartan groups with losartan potassium group blood pressure atbaseline systolic blood pressure showed no significant difference (P=0.1794),in the treatment of8groups in two weeks systolic blood pressure compared withthe baseline period drops somewhat, no statistical difference (P=0.2176), after12weeks of treatment, systolic blood pressure was also decreased significantly,no statistical difference (P=0.7937). Two groups of baseline diastolic bloodpressure showed no significant difference (P=0.1794), in the treatment of8groups in two weeks for diastolic blood pressure compared with the baselineperiod drops somewhat, no statistical difference (P=0.2176), after12weeksof treatment, systolic blood pressure was also decreased, no significantdifference (P=0.7937, described her force irbesartan ester buck effect oflosartan potassium antihypertensive effect similar to. In Allisartan groups, atbaseline,8weeks of treatment and12weeks of treatment of systolic anddiastolic blood pressure were Shuliangliang were statistically analyzed, theresults show that, for8weeks and12weeks blood pressure compared with thebaseline period decreased significantly, with statistical significance (P <0.01),but for8weeks and12weeks, blood pressure did not change significantly,without statistical significance, and losartan potassium results similar to.Conclusion: Allisartan on mild to moderate essential hypertension inpatients with systolic blood pressure decreased significantly; Allisartan on mildto moderate essential hypertension in patients with diastolic blood pressuredecreased significantly;Allisartan and losartan on patients with mild tomoderate hypertension antihypertensive effect of similarity, Allisartan240mg at8and12weeks achieved good antihypertensive effect.