Effect Of Different Classification Methods Of Hilar Cholangiocarcinoma On Resection Rate And Prognosis

Objective:To compare the effect on the choosing of surgery types and prognosis of three different clinical staging methods for hilar cholangiocarcinoma:Bismuth-Corlette typing, the AJCC-7version of TNM staging and the modified T staging. Thus, to evaluate the clinical value of these three methods. Methods:Retrospectively analysis the clinical and pathological data of78patients with hilar cholangiocarcinoma, Classify them with Bismuth-Corlette typing, the AJCC-TNM staging, and the modified T staging respectively; compare their relevance with resection rate and prognosis. Results:The four types of Bismuth-Corlette typing have no significant descending decline of radical resection rate, neither have the three stages of modified T staging. Yet, the radical resection rates of the4stages of AJCC-staging are as followed:100%(11/11).94.7%(18/19),52.9%(9/17) and3.4%(1/29). The resection rates of Ⅰ and Ⅱ stage have no significant difference. The resection rates of Ⅱ stage is significantly higher than Ⅲ stage (P=0.006), while Ⅲ is significantly higher than Ⅳ(P=0.002). The survival function curves of Bismuth-Corlette typing and the AJCC-staging both display several crossing, while the survival curve of modified T staging shows a good parallel decline. The mid-term survival time of T1, T2, T3are42.7813.41,5.61months. The survival time of T1is longer than T2(P=0.034), T2longer than T3(P=0.002).Conclusion:the AJCC-7version of the TNM staging for hilar cholangiocarcinoma is significantly correlated with the resection rate; modified T staging could well predict hilar cholangiocarcinoma patients’ survival time.