Spectral Domain Optical Coherence Tomography To Assess The Association Between The Inner Caliber Of Large Retinal Vessel And The Primary Hypertension

Purpose We explored to assess the" inner caliber" of large retinal vessel quantitatively using spectral domain optical coherence tomography (SD-OCT) and to reveal the association between changes in the" inner caliber" of large retinal vessel and the primary hypertension.Metholds A case-control study was carried out including215cases(with primary hypertension) and210controls (without primary hypertension) admitted to our hospital since2009and all the patients were grouped according to age. SD-OCT was performed to assess the " inner caliber" of large retinal vessel quantitatively including retinal artery inner caliber(RAIC), retinal vein inner caliber(RVIC) and retinal arterio-venous inner caliber ratio(RAVICR).The differences between the cases and the controls in the" inner caliber" of large retinal vessel were analyzed. In the case group, multiple comparison was performed among the patients grouped according to their blood pressure level. How the RAIC and RAVICR change with diastolic and systolic blood pressure were investigated and the RAVICR was also correlated with the following relevant determinants via multiple stepwise regression analysis:age, diastolic and systolic blood pressure and et al. Results In the case group, RAIC and RAVICR were significantly decreased, multiple comparison analysis of variance blood levels revealed a relative difference (p<0.05ANOVA LSD Test) in how the RAIC and RAVICR change with diastolic and systolic blood pressure and at the significance level a=0.05RAVICR was also associated with the diastolic and systolic blood pressure revealed by the multiple stepwise regression analysis (Standardized regression coefficient β=-0.024,-0.019respectively, F=11.231, P=0.001in the ANOVA, the difference was statistically significant).Conclusion Assessing the" inner caliber" of large retinal vessel quantitatively using SD-OCT, we revealed changes in RAI and RAVICR were significantly associated with changes of diastolic and systolic blood pressure in primary hypertension.