Form Controllable Synthesis Of Enamei-liked Fluorapatite And Performance Research

Enamel can be regarded as a natural material with preferential tropism and assembledarray structures. Specific say, it is a one-dimensional nanorods arranged in parallel in space,which is on the scale of nanometer in2D view and on macro-scale level in length. SuchSophisticated structure endows enamel high abrasion resistance, hardness and certain decayresistance ability.In this article, FA enamel prism-like structures with different sizes and shapes wereobtained by using a chemical approach,with EDTA-Ca-Na2, NaH2PO4.H2O and NaF wereused as reactants.The physicochemical property and biological performance of thisenamel-like material were characterized by SEM, XRD, FTIR, XPS, MTT assay, andbacterial inhibition ring test. The results show that we have developed a film of compactedwell-aligned FA crystals, which could grow directly on the surface of enamel. Thesenanorods were approximately6μm in length and300nm in diameter whose physicochemicalproperty and biological performance are similar to natural enamels, at the meantime behavebiological activity and certain bacteriostasis. The product could simulate the feature,component and decay resistance of human tooth enamel prism-like structure, whichdemonstrated the potential of applying nanotechnology to the direct creation of biomaterialswith a specific biological architecture, providing the theory and experimental information forapplications.In summary, we have demonstrated a facile hydrothermal route to the morphology-controlled synthesis of FA nanostructures, which are similar to the natural enamels inChemical composition, microstructure and Biological properties. The present work showswe are able to rebuild the human tooth enamel prism-like structure and enamel-like filmschemically without cells or proteins, which is complementary to the current regenerativemedicine using stems cells. Furthermore, due to its structure and biocompatibility, these FAmicro crystals are expected to be useful to help anti-caries. The simplicity and low cost ofequipments and reagents of this approach may find many novel applications in dental clinics,such as to be used as a substitute for the conventional dental restorative materials to directlyrepair damaged tooth enamel, or used as pits and fissure sealants to prevent caries.