The Investigation Of Transfusion Indications Of The Anemia Of Prematurity

The anemia of prematurity is the common complication of preterminfants,which is divided into the physiological anemia and the pathologicalanemia.One part of the anemia of prematurity which has no symptoms can becalled premature physiologic anemia,but when the anemia of prematurityaccompanies with clinical symptoms, such as skin pale, indifference,difficultyin feeding,poor weight gain,dyspnea,tachycardia,activity reducing,a few caseshave oedema in lower limbs,foot and scrotum and facial region,which is calledpathological anemia and which often needs intervention.The prevention andcontrol of the anemia of prematurity include decreasing phlebotomy losses,drugtreatment and transfusion treatment.Transfusion treatment is one of the mosteffective and common treatment methods,However,our country don’t haveunified transfusion indications of the anemia of prematurity.Most hospitals usethe abroad transfusion indications now,and the abroad transfusion indicationsyet haven’t reach an agreement.The study aims to provide certain clinicalevidence from observing the premature blood transfusions in our hospital andestablish the reasonable and suitable guidelines of the anemia of prematurity inour country.The prematurity who born between October1,2010and October1,2011,admitted within24hours of birth, with length of stay more than or equal2weeks and birth weight less than1500g were rolled into the retrospective study,and divided into two groups according to different indications of bloodtransfusion. There are54cases in observation group1and42cases inobservation group2. From recording the above mentioned prematuirty’s bloodtransfusion, including hemoglobin value before transfusion, the blood transfusions every time,the total transfusion times and the time and the numberof the need of oxygen,synchronous intermittent mandatoryventilation,continuous positive airway pressure,the incidence of apnea,the useof aminophylline,intracranial hemorrhage,periventricular leukomalacia,ductusopen again,the retinopathy of prematuirity,the fungal infection,death,and thehospital days,then make statistical analysis.The measurement date accordingwith normal distribution should be expressed with x±s,the two groups withthe t test,however,the date not according with the normal distribution should beexpressed with M(P25，P75),two groups with the rank sum test,the two groupsof the enumeration date should be expressed with χ2test.After grouping,through comparative analysis the children’s basic situation(gestational age,sex,birth weight,admission based Hct),the children of theobservation group1and the observation group2have no significant differencein birth weight,gestational age,gender,admission HCT.the two groups werecomparable.Then we continue further analysis and draw aconclusion:1.Restrictive blood transfusion can increase the total transfusionvolume and frequency of extremely low birth weight infants.2.Nonrestrictiveblood transfusion may reduce the time of mechanical ventilation in extremelylow birth weight infants,which is beneficial to the recovery of clinicalsympotoms.3.Nonrestrictive blood transfusion may may reduce the incidenceof intracranial hemorrhage,the fungal infection and mortality with theextremely low birth weight infants.