The Relationship Between Uric Acid, Diabetic Nephropathy, Blood Lipid Metabolism And Insulin Resistance

Objective: To explore the relationship between uric acid（UA），diabetic nephropathy, blood lipid metabolism and insulinresistance.Methods: Chose95patients of type2diabetes as a case group anddivide them into three groups according to their UAER in24hours:32patients with normal urine protein (＜30mg/24h);45patients withmicroalbuminuria (30-299mg/24h);18patients with clinical albumin(≥300mg/24h). Set32with normal urine protein as the control group.The fasting glucose, glycosylated hemoglobin, UA, creatinine andurea nitrogen were detected in each group and compared with thatof the control group. Analyzed the levels of UA’s change in differentstages of diabetic nephropathy development.Results: The level of UA in microalbuminuria group and clinicalalbumin were both higher than normal urine protein group (p＜0.05，p＜0.001). But SUA level of the first two groups had no significantdifference（p＞0.05）. Compared with58patients of normal group,the37patients of higher group, their TC, TG, LDL-C, level of plasmainsulin, BMI, HMOA-IR were all obviously higher (p＜0.05，p＜0.01);But their level of HDL were significantly lower than SUA normal group(p＜0.01).Conclusion: The detection of SUA is of significant value to diabeticnephropathy’ s prognostic evaluation, and also has certainrelationship with blood lipid metabolism and insulin resistance.