| Objective: To investigate the effects of calcitriol on the urinary albumin excretion rate(UAER),serum uric acid and homocysteine(Hcy)in patients with early diabetic nephropathy.Methods: Application of randomized double-blind and placebo-controlled methods,a total of 136 patients with early diabetic nephropathy and asymptomatic hyperuricemia(HUA)were selected,and were randomly divided into two groups for the calcitriol or placebo treatments,respectively.Changes in UAER,serum uric acid,Hcy,25(OH)D3,parathyrotropic hormone(PTH)and lipid profile in patients before and after 24 weeks of treatment were measured and compared between groups.Results: There were no statistically significant difference in the baseline clinical characteristics of study participants between two treatment groups(p>0.05 for all).After24 weeks of treatment,comparison of therapy-related differences between groups showed that the calcitriol treatment was more effective in reducing UAER,serum uric acid and Hcy(p<0.05 for all),and increasing the level of 25(OH)D3(p<0.05).Further comparison of therapy-related differences in patients with vitamin D insufficient and deficient between the two groups showed that the calcitriol therapy was better in reducing UAER,serum uric acid,Hcy and PTH,and superior in improving 25(OH)D3 levels than the placebo group.However,compared with the placebo group,the indicators of the calcitriol group had no obvious difference except UAER and 25(OH)D3 in patients with early DN and vitamin D sufficient.Conclusion : Calcitriol treatment can reduce UAER in patients with early diabetic nephropathy and asymptomatic HUA,decrease the levels of serum uric acid and homocysteine in patients with diabetic nephropathy and vitamin D insufficient and deficient,and may exert kidney protection effects. |
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