The Research On The Expression Of P63and MMP-2in Esophageal Squamous Cell Carcinoma And Their Clinical Significance

Esophageal cancer is one of the most common malignant tumor with poor prognosis in the world. China is the high incidence areas.there,most common pathological type is squamous cell carcinoma.In China,the number of deaths of esophageal cancer occupies a proportion of1/4in the total of all cancer mortality. Worldwide each year about30million people died of esophageal cancer, of which50%occurred in China. Esophageal cancer serious harm to human health.In clinical,the most important question about esophageal cancer clinics is that early diagnosis and early treatment,which worthy of most people’s attention and always to be emphasized. Reseacher has reported that early esophageal cancer resection rate can up to100.0%, and the5-year survival rate can be as high as92.6%. Without obvious clinical symptoms of clinical manifestations and lack of specificity, the diagnosis of early esophageal cancer very difficutly.So most of patients miss the best timing of treatment, and led directly to the low5-year survival rate and poor prognosis.Many studies tell us that a variety of cancer genes take important role in the prosess of occurrence and development of esophageal cance, and the expression of these tumor-associated proteins relates with esophageal squamous cell carcinoma development, biological activity, and prognosis. This topic is designed to study the expression of MMP-2and p63and reveal the relationship between the expression and ESCC clinical factors.Then try to investigate its clinical value for the early diagnosis and the judgment of prognosis about esophageal squamous cell carcinoma.In this study, En Vision immunohistochemistry, werstern blotting are used to detect the expression levels of MMP-2and p63gene in esophageal squamous cell carcinoma cancer, paraneoplastic and normal esophageal mucosa, and then analysis the relationship between the expression and ESCC clinicopathologic factors.Our results show that:1, MMP-2and p63genes in normal mucosa, paraneoplastic, and foci of showed incremental expression, suggesting that MMP-2and p63gene may be associated with the occurrence and development of ESCC.2, the expression levels of MMP-2gene in ESCC foci organization correlation with ESCC clinicopathologic factors.3, the expression levels of the p63gene have a close relationship with ESCC clinicopathologic factors.