| ObjectivesOur primary aims were to assess the effect and safety of treatment combined the Xingnaojing injections and Shuxuetong injections for the acute cerebral infarction on clinical condition.Methodthe study was a simple randomized control trial. With the application of Microsoft Excel2003software packages, a total of30acute cerebral infarction cases were randomly assigned into the treatment group and control group at the1:1ratio, each group has15cases. Both groups received the basic treatment (including anti-platelet aggregation, blood pressure controlling, etc). The treatment group patients received intravenous transfusion combining20ml/d Xingnaojing injections and6ml/d Shuxuetong injections for12±2days, while the control group patients received intravenous infusion of10ug/d alprostadil,100mg/d FDP injection, and20ml/d brain protein hydrolyzate for12±2days. We measured before and after the treatment. The measures includes NIHSS score, Barthel Index, improved Rankin Scale score, the grading scale score of TCM syndrome, blood lipid level, the four items of coagulation, hypersensitive C-reactive protein and changes in hemorheology.Findings1. The results indicated significant differences (P <0.05) between the treatment group and control group in NIHSS score, Barthel Index, modified Rankin Scale score by T test and chi-square test, especially the NIHSS scor(?)2. the grading scale score of TCM syndrome revealed that the total effective rate of the two groups are closed to each other, while the obviously effective patients in treatment group are more than those in control group. There is significant difference in chi-square test (P <0.05).3. After the treatment, PT, INR, FIB in both groups shows non-significant difference (P <0.05). The treatment group has the increasing APTT time (P <0.05), while the APTT time in control group remains remain the same level. There is no significant difference of ATPP time between the groups after treatment.4. The data of TC, HLD, DLD, and Apo are also documented to be decreased after the treatment, which shows significant differences (P <0.05), especially the TC and DLD.5. The plasma viscosity of both groups were reduced significantly after the treatment (P <0.05), and the plasma viscosity of the treatment groups enjoyed greater reduction than the control group (P <0.05). the whole blood viscosity at high shear rate, the whole blood viscosity at middle shear rate and Casson viscosity also increased significantly (P <0.05), compared with those in control group.6. During the cure, there isn’t any serious adverse event, like blood loss, but in the control group, one adverse event appeared. The patient felt painful in his hand when having a drip of Alprostadil Fat Emulsiom Injection. After his receiving the right treatment, the symptom disappeared without affecting the clinical treatment.ConclusionThis study supports the same effectiveness of improvement the ability of life of Xingnaojing Injections combined the Shuxuetong Injection, compared with the western medicine. The differences of the effectiveness were non-significant. However the treatment group shows the better result in recovery of nerve function, improvement of TCM symptoms and blood biochemical indicator such as TC and DLD without adverse effect. The study offers a satisfactory treatment for the acute cerebral infarction. |
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