| Aims:Administering Tonifying Kidney Purging (Yishen qingli) Prescription to the patients, added low dose Tripterygium wilfordii polyglycoside simultaneously, treats chronic primary glomerulopathy albuminuria going with the renal deficiency damp-heat syndrome from Traditional Chinese Medicine (TCM) after the management of the RAS blocking agent (ACEI/ARB), depressurization and adjusting blood-fat levels, giving the evidences for reasonable clinical application of the treatment by observing the effects which treats the renal diseases of various pathological types.Methods:74cases of observed patients at every pathological type above10cases, who are UTP<3.0g/24h, serum creatinine<133μmol/L, belonging to the various pathological type chronic primary glomerulopathies with the Renal Deficiency Damp-heat Syndrome by differentiation of symptoms and signs from TCM, are administered Tonifying Kidney Purging Prescription for24weeks, added low dose Tripterygium wilfordii polyglycoside simultaneously, after the treatment of the RAS blocking agent (ACEI/ARB), depressurization and adjusting blood-fat levels, comparing the efficacy that the Prescription treats the patients suffered from the various pathological types of glomerular nephritis by observing the changes of24h UTP and the TCM syndrome integrates of the renal deficiency damp-heat syndrome.Result:(1) Comparing the efficacy of treating the nephropathy, the total effective rate of the74cases is85.1%, IgA (MsPGN)92.3%, IgA (FSGS)86.4%, FSGS80.0%. There are no statistical significance(P>0.05) among the groups;(2) Comparing the TCM syndrome integrate efficacy of treating the nephropathy, the total effective rate is86.5%, IgA (MsPGN)80.8%, IgA (FSGS)100.0%, MsPGN81.8%, FSGS90.0%, There are no statistical significance (P>0.05) among the groups;(3) Comparing UTP of the prior-and post-treatment within the groups of various pathological types of glomerular nephritis, all of P<0.05, there are statistical significance. UTP values within groups of post-treatment in the various time points have statistical significance as well(P<0.05). Comparing the whole UTP means among the groups of post-treatment, there is statistical significance comparing MsPGN with FSGS among various groups, for the rest, all of P>0.05, not statistically significant, presenting that the MsPGN albuminuria is controlled better.(4) All of TCM syndrome integrates of the post-treatment among various groups is declined. Comparing the TCM syndrome integrates of the prior-and post-treatment of FSGS, there are statistical significance (P<0.05), being high statistical significance (P<0.01) in the comparisons of the prior-and post-treatment of IgA (MsPGN), MsPGN, IgA (FSGS) respectively. Comparing the TCM syndrome integrate differences of the prior-and post-treatment among the groups, there are no statistical significance (P>0.05) Conclusion:①Administering Tonifying Kidney Purging (Yishen qingli) Prescription to the non-nephropathy patients, added low dose Tripterygium wilfordii polyglycoside, treats chronic primary glomerulopathy going with the renal deficiency damp-heat syndrome from TCM after the management of the RAS blocking agent etc., has better efficacy of controlling albuminuria, the total effective rate being85.1%, improving the symptoms of the patients with the renal deficiency damp-heat syndrome as well, the total effective rate being86.5%.②By comparing the albuminuria of the post-treatment of various pathological type nephropathy, the efficacy suggests that the MsPGN is more significant. |
