The Expression And Significance Of Wnt3a, Beta Catenin And CyclinD1of Colorectal Cancer

Objective:To study the expressions and the distributions of Wnt3a、β-catenin and CyclinDi about colorectal cancer and the clinical significance of them.Methods:Make use of a method which is called immunohistochemical S-ABC method to detect the expressions and the distributions of Wnt3a、β-catenin and CyclinDi protein about colorectal cancer.Results:The expression of wnt3a protein has been failed to detect in the benign lesion tissue of colon and rectum,which showed different degree of immunoreactivity in the colon and rectum tissue;However,the beta catenin, CyclinD1protein can be expressed both in the benign colorectal lesions and in the cancer tissues;The expression of beta catenin,CyclinDi protein in carcinoma tissue was significantly higher than in the benign lesion tissue;The expression of Wnt3a,beta catenin, CyclinDi protein have no interrelationship with age, sex, Dukes staging,lymphonodus metastasis,and distant metastasis of the patients with colon and rectum cancer(P>0.05), while have correlationship with the size and the degree of differentiation of the tumor of colon and rectum cancer(P<0.05).Conclusion: Wnt3a, beta catenin, CyclinDi protein obviously are up-regulated in the tissue of colorectal cancer, It is important to detect the expressions and the distributions of Wnt3a、β-catenin and CyclinDi in the tissues of colorectal cancer,which may offer important cases to the illness, treatment and prognosis of the colorectal cancer.