| Objectives:In order to detect amnestic mild cognitive impairment(aMCI) earlier andprovide the best time window for prevention and treatment, this study usedresting-state functional magnetic resonance imaging (fMRI) to explore the neuralnetwork structure and functions in aMCI patients. Meanwhile, it also contributes tobetter understanding of cerebral activity.Methods: In this report, ten aMCI patients and ten normal aged people were selectedby neuropsychological assessment among outpatients and inpatients from September2010to December2011. The resting state fMRI test (3.0T) were performedto investigate patients’ image data for the regional homogeneity (ReHo) of cerebralfunctional networks. Furthermore, the difference in cerebral activity between aMCIpatients and normal aged people were compared.Results: Compared with aMCI patients,increased ReHo were found in normal agedpeople in the regional homogeneity in posterior cingulate, medial frontal lobe, medialprefrontal cortex and part of parietal lobe. However, for aMCI patients,the ReHo inleft temporal lobe(middle temporal gyrus and inferior temporal gyrus),leftparahippocampal gyrus,occipital lobe,lingual gyrus and cuneus decreased, whereasthe ReHo in right frontal lobe(inferior frontal gyrus), left superior temporalisgyrus,precentral gyrus,right thalamus and left fusiform gyrus increased whencompared with healthy controls.Conclusions: In the resting state, the ReHo in posterior cingutate, medial frontallobe, medial prefrontal cortex and part of parietal lobe increased significantly in bothnormal aged people and aMCI patients, which suggests that there is an acquiescentnetwork with spontaneous activities in brain,which is consistent with previous studies.Moreover, the difference of ReHo in the regions among aMCI patients in resting stateindicates that there is an abnormality with their abnormal acquiescent network. Itprovides foundations for selecting potential interesting regions of the brain to conductfunctional connectivity studies. |
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