Ultrasound Diagnosis Of Fetal Limb Malformations And The Correlation Between Fetal Limb Malformations With The Chromosome

ObjectiveAlong with various internal and external factors, fetal malformation incidence continuesto increase, every family want to have a health baby, and ultrasound is the preferredimaging prenatal diagnosis methods, in the prenatal examination has more advantages,it can eliminate most show structural abnormalities of the deformity, and onchromosomal abnormalities have a highly pointing function.The research for assess theeffectiveness of ultrasound diagnosis of fetal limb malformations and the correlationbetween fetal limb malformations with the chromosome.MethodsIn2010February-2011November came to our hospital for prenatal screening for5846cases of pregnant women， fetuses were checked using Lishengli’s systematiccontinuous sequence approach prenatal ultrasonography. When necessary and withreal-time3D imaging technology routine examination, focusing on the developmentsituation and posture, and all systems of the body are detailed and comprehensiveexamination.Discovery of fetal limbs malformations were followed-up.Suggestions forits line of invasive chromosome examination,18-23weeks suggested amniotic fluidchromosome examination,23weeks after recommendations underwent ultrasoundguided puncture of umbilical vein blood cell chromosome examination. A random sample of prenatal ultrasound screening of fetal completely normal tips but have otherrisk factors of400patients were followed up. All follow-up of fetal birth and afterinduction of labor with gross specimen alignment, and with the invasive chromosomeexamination results analysis.Results5846cases of fetal limb malformations in34cases (0.58%), and after abortionspecimens compared to ultrasound diagnosis coincidence rate is100%;30cases of fetalchromosomal examination,22cases of normal chromosome (73.3%),8cases withchromosome abnormalities karyotype, abnormal rate was26.7%. In400cases of normalfetal ultrasonography in121cases of invasive fetal chromosome examination, only1cases of abnormal chromosome karyotype, abnormal rate of0.82%.Limb malformationsof fetal chromosomal abnormalities had a significantly higher incidence of limb innormal fetuses, and the difference was statistically significant (P <0.001). Alsoaccording to specific structural malformations in combination can be inferred fromanalyzing the possible abnormal chromosome karyotype.ConclusionsThe fetal limb malformations are characteric on ultrasound screening， Using asystematic continuous sequence detection method with real-time3D imaging cangreatly improve the detection rate of limb malformation, Ultrasound screening withoutdamage, and the method is simple, the price is appropriate, but for the vast majority oflimb malformation diagnosis of exclusion, safety is widely used in the whole pregnancy,prenatal diagnosis is currently the most effective and safe means of screening for fetallimb deformity, is the preferred method of. Fetal limbs malformations ave often associated with other organ malformations associated with the presence of chromosomalabnormalities, and has a certain relation, can be used as the important indications offetal chromosome screening. Ultrasound screening and chromosome karyotype analysisof the combination of the two will aid in the detection of fetal genetic diseases.