Clinical And Experimental Study On Li Chang-yin In Treating Visceral Hypersensitivity Of Diarrhea-Irritable Bowel Syndrome

Objective:In this paper, based on previous studies, both from clinical and animalexperiments to further evaluate the efficacy of Li Chang-yin in Treating diarrhea-irritablebowel syndrome (D-IBS), and Observe the intervention on visceral hypersensitivity, andthe science of theoretical and experimental basis for Chinese medicine treatment of thedisease.Methods:(一)Clinical research:160patients met the inclusion criteria were randomlydivided into experimental group (80cases) and control group (80cases), respectively, giveLi Chang-yin and Dicetel(Pinaverium bromide) oral treatment lasted four weeks.Observedafter treatment there are always efficiency and efficacy of TCM symptoms, adversereactions and the relapse rate.(二)Experimental study:120rats were randomly divided into blank control group(group A,20); model control group (group B,20);Li Chang-yin, in the Low, medium andhigh dose group (C and D and Group E,20); western medicine the Dicetel group (group F,20).Using colon chronic stimulation modeling,after modeling success each group to itscorresponding drug orally,after2weeks observed the changes in the serum, colon tissue5-HT, SP levels.(三)Resuit:(一)Results of clinical studies show:1.After treatment, the total efficiencycompared: the experimental group was91.25%and71.25%in the control group, theexperimental group than the control group, the difference was statistically significant (P<0.01).2.The two groups in the TCM Syndrome, total symptom score were improved aftertreatment than before treatment (P <0.01or P <0.05).The experimental group after treatment in improving patients with abdominal distension vector gas, Xiong Xie zhangmen, depression, irritability, fatigue lazy words appetite appetite terms of efficacy than thecontrol group (P <0.01or P <0.05).3.Two sets of incidence of adverse reactions comparedto the experimental group than the control group (P <0.05).4Two sets of recurrence rate:The experimental group was11.63%in the control group was47.37%, the experimentalgroup than the control group (P <0.01).(二)Experimental results show:D、E and F, can be varying degrees of lower modelserum and colon tissue of5-HT, the SP content, elevated CGRP levels,(P <0.01or P<0.05).Group E is batter than Group D, the difference was statistically significant (P<0.01).But Group E compered with Group F showed no significant difference (P>0.05).Conclusion:Li Chang-yin is safe and effective prescription of the treatment ofD-IBS.Its mechanism of action by reducing the serum and colon tissue of5-HT, SP content,elevated CGRP levels, so that the excitability of neurons weaken, thereby enhancing thevisceral pain threshold, reduce visceral hypersensitivity, and to achieve the purpose oftreatment of D-IBS.