Effects Of Diet Interventions On Glycemic Control And Cytokines Changes In Patients With Type2Diabetes Mellitus

Objective To explore the effects of Low-glycemic index(LGI) and low glycemic load(LGL) diet intervention on glycemic control and cytokines changes in patients with type2diabetes mellitus (T2DM).Methods This study was a randomized control study. There were105patients with T2DM were selected to be samples from Jin Pen Ling Sanzhen community, Changsha city. The patients were divided into three groups randomly:the whole day group (n=35), the breakfast group (n=35) and the control group (n=35). Interventions included patients educations and different dietary. The whole day group and the breakfast group were educated with the knowledge of the GI and the glycemic load(GL). Furthermore, we made the personal dietary of the whole day based on low glycemic index (LGI) and low glycemic load (LGL) for the whole day group; we made the personal dietary of the breakfast based on LGI and LGL for the breakfast group, the other meals of this group were chosen by themselves; The program gave the control group without any intervention in this study. Before and after intervention, compared the differences of BMI, waist-hip ratio, fasting blood glucose (FBG), postprandial2hours blood glucose (2hPBG), glycosylated hemoglobin (HbAlc),inflammatory factors including Tumor Necrosis factor (TNF-a), C reative protin (CRP) and Interleukin-6(IL-6). Results After interventions, the serum BMI and WHR serums levels serum decreased in the breakfast group and the control group, levels of HbAlc decreased in three groups (p<0.0167), HbAlc, TNF-α, CRP, IL-6in the whole day group were lower than those in the breakfast group and the control group (p<0.0167), serum levels of TNF-a, CRP in the breakfast group were lower than those in the control group (p<0.0167), and it was lower in the intervention group than that in the control group. The effect showed in the treated group was also superior to that in the control group (p<0.0167).Conclusion LGI and LGL diet may be effective on blood glucose control and serum levels of inflammatory factors, relieve inflammatory response.