Evaluate The Clinical Effects Of Dministration Of2-MHz Pulsed-wave Transcranial Doppler Monitoring Continuo-usly After Arterial Thrombolytic Therapy In Patients With Acute Cerebral Inf-arction

Objective:We sought to evaluate the clinical effects of administration of2-MHz pulsed-wave transcranial Doppler (TCD) monitoring2hours after intra-arterial thrombolysis therapy in patients with acute ischemic stroke attributed to anterior circulation occlusion.Methods:We evaluated40patients with acute ischemic stroke attributed to anterior circulation occlusion, which were treated with urokinase by intra-arterial thrombolysis therapy during December2010December to2011in Haikou City People’s Hospital. All of patients were divided into2groups completely randomly, one group which were included20patients were given2-MHz pulsed-wave transcranial Doppler (TCD) monitoring2hours after intra-arterial thrombolysis therapy immediately. And all the patients were marked with National Institute of Health stroke scale(NIHSS) before and after intra-arterial thrombolysis therapy (2h,24h,7d,14d); all the patients were given CT examination in three days and TCD examinations after intra-arterial thrombolysis therapy immediately,and the time2h,24h were be repeated.Results:The group which were given2-MHz pulsed-wave transcranial Doppler (TCD) monitoring continuously after ntra-arterial thrombolysis therapy had lower NIHSS score(2.8±2.0) compared with the group(8.1±9.9) which were only given ntra-arterial thrombolysis therapy with urokinase after14days (P<0.05). and the ratio (5.26%)of re-infarction patient was lower than the control group (35%); intracranial hemorrhage rate (10.52%) was higher (5%) than the control group (P>0.05).Conclusions:The patients with acute ischemic stroke were given2-MHz pulsed-wave transcranial Doppler (TCD) monitoring2hours after intra-arterial thrombolysis have better clinical effect compared with the patients which were only given arterial thrombolytic therapy with urokinase.