| Objective to observe the depressed patients age, sex and TCM diagnosis and classification of distribution; Analyze XINYUE Granule1-5ameliorating the grades of HAMD scale, TCM syndrome type and its adverse drug reaction. Comparative study the efficiency between the experimental group TCM syndrome types and control group TCM syndrome types from HAMD scale,SDS scale, TCM symptom score scale in the56th day, and monitoring the adverse reactions and security situation.Methods275patients are divided into two groups, one is experimental group including133patients which take XINYUE Granule1-5were seperated into5TCM syndrome types:Liver qi stagnation22eases, liver depression and spleen deficiencies17cases, liver depression and phlegm obstruction35cases, deficiency of both the heart and spleen18cases, noninteraction of heart and kidney41cases. Another was control group including115patients which take hydrochloric acid prozac:Liver qi stagnation20eases, liver depression and spleen deficiencies18cases, liver depression and phlegm obstruction33cases, deficiency of both the heart and spleen19cases, noninteraction of heart and kidney34cases, a total of56days observation. Before treatment respectively0days (baseline period),7days,28days,56days to patients were done HAMD scale, TCM symptom scores, SDS scale. Watch the final group and control group of TCM syndrome differentiation points TCM syndrome differentiation points HAMD scale, TCM symptoms of integral and SDS scale curative effect, and compared statistical software for analysis.Results1.257cases of depression in the observer, the male82cases,175cases of women, women were significantly more than male patients, the age between31and60years old is the biggest potion. TCM syndrome type distribution proportion with liver depression and phlegm obstruction, noninteraction of heart and kidney have the most patients in five TCM syndrome types.2. HAMD scale effect analysis:all patients in the experimental group and control group, the final and observation period compared to baseline score, were obviously reduce (P<0.01). The clinical control rate, remarkable progress rate in the experimental group were significantly higher than the control group (P<0.05); Progress rate, no efficiency rate were significantly lower than the control group (P<0.05). Experimental group total effectiveness (93.98%) was much higher than those in the control group (83.43%)(P<0.01). All of the patients in the experimental group of seven days to the baseline period was the mean score, were significantly reducing (P<0.05or <0.01). The control group subjects in drug by28days, integral mean and baseline period was obviously reducing (P<0.05or0.01).3. TCM symptom scores effect analysis:all patients in the experimental group and control group, the final and observation period compared to baseline score, were obviously reduce (P<0.01). Clinical cure rate, the methodological significant efficiency were significantly higher than the control group (P<0.05or<0.01); Progress rate, no efficiency rate significantly lower than in control group (P<0.05or <0.0l). The total effective rate (93.23%) in experimental group was significantly higher than the control group (85.48%)(P<0.05).Liver depression and phlegm obstruction, deficiency of both the heart and spleen and noninteraction of heart and kidney in experimental group, seven days to the baseline period is the mean score, were significantly reducing (P<0.05or<0.01). The group Liver qi stagnation and liver depression and spleen deficiencies in experimental group and all patients in control group,28days integral mean and baseline period have a significant decrease in comparison (P<0.05or<0.01).4. Analyze of the efficacy between the experimental group TCM syndrome types and control group TCM syndrome types from HAMD scale in the56th day:the clinical efficiency of liver depression and phlegm obstruction and noninteraction of heart and kidney in the experimental group were higher than the control group (P<0.05) Analyze of the efficiency between the experimental group TCM syndrome types and control group TCM syndrome types from TCM symptom score scale in the56th day: the clinical efficiency of liver depression and spleen deficiencies in the experimental group are higher than the control group (P<0.05). Analyze of the efficiency between the experimental group TCM syndrome types and control group TCM syndrome types from HAMD scale in the56th day:the clinical efficiency of Liver qi stagnation, noninteraction of heart and kidney in the experimental group were higher than the control group (P<0.05)5. Adverse drug reaction analysis:adverse drug reaction rate in experimental group was9.77%, and the control group was25.81%. Adverse drug reaction rate in experimental group was lower than control group (P<0.01). Two groups of patients before and after treatment, kidney and liver function of routine blood, electrocardiogram, there were no significant difference results show that.Conclusion1. XINYUE Granule1-5diagnosis and treatment of depression had better effect than prozac, and work fast;2. XINYUE Granule1-5for improving the same type of TCM syndrome had better effects than with prozac, explain to improve TCM clinical syndrome treatment more have specific aim, and western medicine treatment there exist certain limitation;3. XINYUE Granule1-5in clinical study found no poison, side effects and adverse reaction rates low for the treatment of depression have more broad prospect. |
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