Expression Of VEGF And Significance Of MVD In Human Pterygium

Objective:To investigate the expression of vascular endothelial growth factor (VEGF) role and microvessal density(MVD) in pterygium genesis and progression.Methods:Immunohistochemical S-P method was used to evaluate expression of VEGF and CD31was used to determine MVD in47cases of pterygium (progressive stage group, N=30,resting stage group, N=17) and20cases of normal tissues.Results:The expression rate of VEGF in pterygium and normal groups was85.1%and20.0%, respectively, there was significant differences between the two groups (P<0.05); The expression rate of VEGF in progressive stage group was96.7%and in resting stage group was64.7%, respectively, there was significant differences between two groups (P<0.05); The expression rate of VEGF in I, II, III groups were50.0%,87.5%and92.0%, respectively, There were significant differences among three groups (P<0.05). MVD value was12±6.56and4.60±1.53in pterygium and control groups, respectively, there was significant differences between two groups (P<0.05). The MVD value was19.60±6.78and9.58±2.52in progressive stage and resting stage groups, respectively, there was significant differences between two groups (P<0.05); The MVD value was11.32±1.25,18.93±2.59,19.96±6.32in the phase I, Ⅱ and Ⅲ groups, respectively, there were no statistically differences in three groups (P>0.05).There was positive correlation between expression of VEGF and MVD value in pterygium(r=0.594, P<0.05).Conclusions:There was positive correlation between expression of VEGF and MVD value in pterygium, and the results suggested that the neovascularization play a important role in pterygium genesis and progression.