Clinical Research Of Winter Timing Shikishima Treatment In Children With Primary Nephrotic Syndrome

Objective:Observe renal apply spirit winter an apply stick and moxibustion therapy50cases of children of the nephrotic syndrome (spleen and kidney deficiency of both type) of safety and to evaluate its curative effect, as so to discuss TCM medicine of traditional Chinese medicine combined with external treatment time in children nephrotic syndrome in the clinical significance.Methods:Hubei province pediatric hospital outpatient department and choose the inpatient department nephrotic syndrome differentiation of children of the spleen and kidney deficiency of both type50cases, randomly divided into three groups, namely an treatment group, the choice of treatment group and control group when. An treatment group:in the original combine traditional Chinese and western medicine medicine (hormones long-range therapy and Chinese medicine cream party kidney) basis to renal apply spirit external treatment. Specific apply posted time is:the annual lunar November to January of next year’s three months before the next seven days a month for a time, every year,29Celsius, the first day of the injected each apply a, all in daily9a.m. to3when between use of the afternoon, and the meridian take god que, close yuan, bilateral renal yu, double spleen yu, double springs, three Yin/, foot three mile, every time apply6-24hours. Add the dressing and are a drug hub, every time jiu1,2strong (medicine in placard YiZhu intercepted1.5cm long for a strong, and lit burns out so far); The timing treatment group:treatment group and an preparation method is same, only a year with the time apply posted sticks is not restricted. The control group:only in the original combine traditional Chinese and western medicine treatment of internal medicine.Observe three groups before treatment, the treatment of children of the6months, a year of each index. Including (1) the safety index:the general medical project, routine blood, kidney, liver function examination, the whole body reaction;(2) the curative effect of observation:the total symptoms and various points of sickness integral change (the complexion, diet, defecate, night urination, tongue pulse, etc), and calculation clinical curative effect, disease outcome, recurrence people, and urine beta2-MG, serum IgG, blood cortisol levels (8Am), zinc, copper blood level of blood, blood rheology and fibrinogen and the change of the laboratory parameters.Results:1. The three groups before treatment clinical general material (gender, age, clinical classification) and sickness integral baseline between traditional Chinese medicine group is, there were no statistical difference (P>0.05), comparable.2. Safety evaluation:except two cases in children is local have mild SAO is urticant feeling (after withdrawal disappear) outside, the more found no discomfort, routine blood, liver function, kidney all normal, show that kidney apply spirit apply stick treatment safety, non-toxic side effects.3. The evaluation of clinical curative effect:the total score of traditional Chinese medicine and most points sickness symptoms after treatment is the integral in before treatment, are obviously decrease (P<0.05), among them with the complexion, infections frequently, albuminuria improve the most significant, and apply posted in treatment group stool, improve uria, tongue better than control group, indicating that the pulse of combining traditional Chinese and western medicine therapy in improving spleen and kidney deficiency of both state which has curative effect, and apply stick than without the apply to stick. The treatment group compared with the total score symptoms improved significantly (P<0.05), the complexion, infections frequently, defecate and proteinuria index fell obviously, sickness integral parts in reducing the number of infections in the treatment group was higher than the choose an treatment group; An treatment group is a year after clinical significant efficiency high (P<0.05), the treatment of disease and treatment during remission rate a year after people are significantly better in the recurrence (P<0.05).4. Experimental evaluation index:urine beta2-MG level after treatment group is a year compared with before treatment significantly reduced (P<0.05); Treatment treatment group is lower during the control group (P<0.05), one year after treatment timing treatment group significantly lower than in control group (P<0.05). The level of serum IgG treatment group than during treatment before treatment increased (P<0.05), one year after treatment group level and before treatment significantly compared rise (P<0.05); But three comparative differences between the way was not statistically significant (P>0.05). Blood group after treatment cortisol levels are rising trend, the treatment of choice... when the treatment group before treatment is increased significantly (P<0.05), one year after treatment two treatment group level and before treatment are more significantly increased (P<0.05); But three comparative differences between the way was not statistically significant (P>0.05). Blood zinc, copper level after treatment, the blood are rising, and an treatment group blood level of zinc one year after treatment than before treatment (P<0.05); But three comparative differences between the way was not statistically significant (P>0.05). Plasma viscosity value, RBC gathered index, FIB three index an treatment group one year after treatment with before treatment were significantly lower compared (P<0.05), the timing treatment group FIB level one year after treatment is lower before treatment (P<0.05); But the three indexes comparative differences between groups were no statistically significant (P>0.05).Conclusions:Renal apply spirit an winter apply points safe and effective and ensure effective children improve TCM clinical symptoms and infections frequently, so as to reduce the recurrence people, and through the blood, serum cortisol increase blood level of zinc, IgG, lower urine beta2-MG value and blood viscosity, to improve the deficiency of the kidney and blood stasis state, strengthen the immune function, so as to improve the significant efficiency, improve disease prognosis and outcome.