Protective Effects Of Erdosteine Preconditioning On Myocardial Ischemia-reperfusion Injury In Rats

Objective： To investigate the effects of erdosteine preconditioningon myocardial ischemia-reperfusion injury and myocardial apoptosis inrats.Methods：30male Sprague–Dawley rats were randomly dividedinto three groups：sham operation group(Ctrl),ischemia-reperfusiongroup(IR) and erdosteine preconditioning group(E+IR). The leftanterior descending coronary artery was ligated for30minutes andthen loosed for120minutes to establish the model of myocardialischemia-reperfusion injury in rat.The contents of maleic dialdehyde(MDA) in serum and myocardial, the activities of superoxidedismutase (SOD)、glutathione peroxidase (GSH-PX),catalase (CAT) inserum and myocardial, the activities of creatine kinase（CK）and lactatedehydrogenase（LDH）in serum were detected at reperfusion120minutes. TUNEL were used to detect the myocardial apoptosis index.Results： Erdosteine preconditioning significantly reduced thecontents of MDA in serum and myocardial (P＜0.05), reduced theactivities of CK and LDH in serum (P＜0.05,P＜0.01）,enhanced the activities of SOD,GSH-PX,CAT in serum and myocardial（P＜0.05,P＜0.01), reduced the myocardial apoptosis index（P＜0.05）.Conclusion： Erdosteine preconditioning has protective effects onmyocardial ischemia-reperfusion injury in rats，and has protectiveeffects on myocardial apoptosis that induced by oxygen free radical.