Correlation Of Pretreatment Sccag With Clinical-pathological Characteristics Of Squamous Cervical Cancer And Its Role In Predicting Lymphnode Matastasis In Early Stage Diseases

ObjectiveTo discuss the relationship between pretreatment SCCA and biologicalcharacteristics of patients with cervical cancer, and to investigate its role inpredicting lymph node metastasis in early stage diseases.MethodsData from409patients with uterine cervical cancer was collected. Theassociation of pretreatment SCCA with FIGO stage was analyzed. Amongthese,88patients of early stage diseases with radical surgery as primarytreatment were further investigated to evaluate the role of pre-treatmentSCCA in predicting recurrence risks, including lymph node involvement,which had been evaluated mainly through CT/MRI scanning.ResultSignificant correlation was found between pretreatment SCCA leveland clinical stage, tumor size, depth of cervical stromal invasion, involvement of lymph node(P＜0.05); no correlation was found betweenthe pretreatment SCCA and the pathologic grade(P=0.73). After adjusted bymultivariate analysis, pretreatment SCCA was proved the only independentrisk factor of the lymph node metastasis (P=0.048). When the cut-off pointwas set as2.25ng/ml, the sensitivity was70%, specificity was78.2%, thepredictive value was proved best. As compared, the sensitivity and thespecificity of imaging examination to diagnose the lymph node metastasiswere40%and91%, respectively.ConclusionPretreatment SCCA is helpful for evaluating the biologicalcharacteristics of patients with squamous cervical cancer. Compared withtraditional CT/MRI imaging, SCCA presents with higher sensitivity inpredicting lymph node matastasis.